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diagnosis rheumatology vasculitis differential lupus clinical cryoglobulinemia cryoglobulins erythematosus granuloma indications majocchis management microscopy nephritis nephrology photo rubrum sjogrens syndrome
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
tract, and often causes ... Urticaria and hypocomplementemia ... against MPO • Complement ... vasculitis, and SLE ... #rheumatology #classification
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
activate the immune system ... • They can cause ... Cryoglobulins Cause ... • Low serum C4 complement ... diagnosis #types #classification
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... anti-Smith Ab, low complements ... Skin Disease Classification ... RNP antibodies, Complement ... • Kidney biopsy
Lupus Nephritis - Diagnostic approach to kidney disease associated with systemic lupus erythematosus (SLE) SLE patient develops
associated with systemic ... , WBC casts) especially ... Perform Kidney Biopsy ... Nephritis #diagnosis #algorithm ... #biopsy #indications
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
diseases, such as SLE ... ESR > 50mm/hr • Biopsy ... tract, and often causes ... Elevated AST ALT • Hypocomplementemia ... Vasculitis) • Hypocomplementemic
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
overlaps with RA, SLE ... salivary gland) biopsy ... Cytopenia: 2% • Hypocomplementemia ... • Can cause TYPE ... salivary gland) biopsy
Majocchi’s Granuloma due to Trichophyton rubrum This is GMS stain and culture of a skin biopsy
culture of a skin biopsy ... + tinea pedis Biopsy ... tissues - mainly caused ... - Systemic Rx ... Competent and compromised
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