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diagnosis differential classification rheumatology eosinophilia hypersensitivity pulmonary reactions types associations connectivetissuediseases ctild diseases druginduced endocarditis eosinophilic gi ild ileitis infective
Hypersensitivity Types and Their Mechanisms Type I - lgE - Soluble antigen - Allergen-specific lgE antibodies bind
- Local and systemic ... antigen, leading to complement ... Complement activation ... arthritis, and systemic ... Diagnosis #Reactions #Table
Summary table of types of hypersensitivity reactions. Type 1 - Mediators: lgE - Antigen Form: Soluble
Summary table of ... they activate complement ... glomerulonephritis, Systemic ... #table #classification ... #comparison
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
90% - Low complement ... months to years) Systemic ... 80% - Low complement ... management of SLE ... #comparison #table
Eosinophilia - Differential Diagnosis Algorithm Idiopathic Eosinophilia Primary Eosinophilia: • Primary hypereosinophilic syndrome • Eosinophilic Leukemia • MPN/MDS
Differential Diagnosis Algorithm ... B-cell lymphomas), Systemic ... histiocytosis • Allergic ... , Sarcoidosis, SLE ... #allergy
Connective tissue disease-associated interstitial lung diseases LIP: lymphoid interstitial pneumonia. NSIP: nonspecific interstitial pneumonia. OP: organizing pneumonia.
SSc: systemic sclerosis ... rheumatoid arthritis SLE ... : systemic lupus ... #Differential #Comparison ... #Table #Pulmonary
Causes of ileitis beyond Crohn’s disease and infections include systemic disorders -spondyloarthropathies, vasculitides, ischemia, and amyloidosis
infections include systemic ... See below for table ... helpful paper complements ... #Differential #Table
Approach to Eosinophilic Lung Diseases • Acute Eosinophilic Pneumonia (< 1 wk) - ~30yo, M; Recent
loss, malaise • Allergic ... , hemoptysis; +systemic ... in 40%, mild; +systemic ... differential #diagnosis #comparison ... #table #eosinophilia
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
often involved • Hypocomplementemic ... Urticaria and hypocomplementemia ... central nervous system ... against MPO • Complement ... vasculitis, and SLE
Differentiating NBTE from Infective Endocarditis No pathognomonic signs/symptoms or echo features that are specific to NBTE, and
conditions: Autoimmune (SLE ... features: Fever -, Systemic ... features: Fever +, Systemic ... #Endocarditis #comparison ... Marantic #diagnosis #table
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