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diagnosis differential rheumatology hematology management dermatology lupus neurology nephrology secondary systemic testing thrombocytopenia bruising classification druginduced erythematosus fatigue glomerular glomerulonephritis
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
• They can cause ... Cryoglobulins Cause ... diseases: - 10% SLE ... • Low serum C4 complement ... erythematosus (SLE
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
tract, and often causes ... often involved • Hypocomplementemic ... Urticaria and hypocomplementemia ... against MPO • Complement ... , and SLE) • Urinalysis
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
, vascular disorders ... , coagulation disorders ... , or other causes ... Splenomegaly - CTD (SLE ... Associated - SLE
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
and Platelet Disorders ... Diagnosis and Workup ... test, ANA (e.g., SLE ... primary hematologic disorder ... #Workup #hematology
Causes of Bleeding / Bruising - Differential Diagnosis Algorithm Thrombocytopenia - Quantitative Defect • Decreased Production •
Causes of Bleeding ... Differential Diagnosis Algorithm ... Sequestration Disordered ... • Steroids • Vasculitis ... #Causes #Hematology
Causes of Excessive Daytime Sleepiness - Differential Diagnosis Algorithm Insufficient Sleep • Poor Sleep Hygiene • Insomnia
Causes of Excessive ... Differential Diagnosis Algorithm ... Shift Work) Sleep ... Differential #Diagnosis #Algorithm ... #Causes
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
• Immunologic Workup ... 90% - Low complement ... Discontinuation of causal ... • Immunologic Workup ... 80% - Low complement
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
pathophysiologic causes ... staining): • Low Complement ... Idiopathic • Normal Complement ... Glomerulonephritis #Vasculitis ... differential #diagnosis #algorithm
Causes of Approach to Altered Level of Consciousness - Workup Clinical Exam - Focal • Trauma •
Causes of Approach ... Consciousness - Workup ... Hemorrhage • See ... Refer to Blood Work ... #algorithm #Causes
Causes of Secondary IgA Nephropathy - Differential Diagnosis Algorithm • GI disorders: Celiac disease, Crohn's disease,
Causes of Secondary ... Differential Diagnosis Algorithm ... • GI disorders ... spondylitis, RA, SLE ... #Nephropathy #Causes
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