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diagnosis rheumatology comparison lupus types allergy erythematosus hypersensitivity management reactions vasculitis coccidioidomycosis criteria cryoglobulinemia cryoglobulins differential druginduced endocarditis eularacr granuloma
EULAR/ACR Classification Criteria for Systemic Lupus Erythematosus Clinical Domains: • Constitutional domain: Fever • Cutaneous domain: Non-scarring
EULAR/ACR Classification ... Erythematosus Clinical ... Constitutional domain: Fever ... anticoagulant • Complement ... #Criteria #SLE
Hypersensitivity Types and Their Mechanisms Type I - lgE - Soluble antigen - Allergen-specific lgE antibodies bind
- Local and systemic ... , seasonal hay fever ... Complement activation ... Hypersensitivity #Types #Classification ... Diagnosis #Reactions #Table
Summary table of types of hypersensitivity reactions. Type 1 - Mediators: lgE - Antigen Form: Soluble
Summary table of ... Anaphylaxis, Hay fever ... glomerulonephritis, Systemic ... types #allergy #table ... #classification
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
to 1:1 F:M • Clinical ... 90% - Low complement ... months to years) Systemic ... 40, F:M 9:1 • Clinical ... #comparison #table
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
Coronary arteries - Fever ... Vasculitis: • Fevers ... against MPO • Complement ... vasculitis, and SLE ... #rheumatology #classification
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... ) Suspect: Clinical ... weight loss, and fever ... anti-Smith Ab, low complements ... Skin Disease Classification
Differentiating NBTE from Infective Endocarditis No pathognomonic signs/symptoms or echo features that are specific to NBTE, and
conditions: Autoimmune (SLE ... features: Fever ... -, Systemic embolism ... features: Fever ... Marantic #diagnosis #table
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
activate the immune system ... Syndrome: • Clinical ... • Low serum C4 complement ... erythematosus (SLE ... diagnosis #types #classification
Coccidioidomycosis (Valley Fever) - Diagnosis and Management Summary WHAT? • Coccidioidomycosis due to Coccidioides immitis or Coccidioides
the lymphatic system ... Central nervous system ... analysis using complement ... TREATMENT: Clinically ... stable patients
Majocchi’s Granuloma due to Trichophyton rubrum This is GMS stain and culture of a skin biopsy
No fever. ... recommended as sole ... - Systemic Rx ... Competent and compromised ... recommended Mayo Clinic
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