19 results
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
- Differential ... Urticaria and hypocomplementemia ... Coronary arteries - Fever ... : • Fevers • ... against MPO • Complement
Pulmonary Renal Syndromes and Mimics - Differential Diagnosis Framework
Diffuse alveolar hemorrhage + rapidly progressive glomerulonephritis
90%:
 -
Syndromes and Mimics - Differential ... anti-GBM) 10%: - Low Complement ... - Normal Complement ... other hemorrhagic fevers ... Syndromes #Mimics #Differential
Vasculitis - Differential Diagnosis Framework

When to Consider Vasculitis:
• Purpura, ischemic skin lesions
• Mononeuritis multiplex
• Hematuria, proteinuria,
Vasculitis - Differential ... Differential Diagnosis ... Elevated AST ALT • Hypocomplementemia ... ) • Hypocomplementemic ... inflammation Hypersensitivity
Rapidly Progressive Glomerulonephritis (RPGN)
RPGN has three primary pathophysiologic causes differentiated by immunofluorescence

Immune Complex Mediated (granular staining):
staining): • Low Complement ... Idiopathic • Normal Complement ... Glomerulonephritis #Vasculitis ... #differential # ... diagnosis #algorithm
Summary table of types of hypersensitivity reactions. 
Type 1
 - Mediators: lgE
 - Antigen Form: Soluble
Summary table of ... types of hypersensitivity ... Anaphylaxis, Hay fever ... they activate complement ... types #allergy #table
Hypersensitivity Types and Their Mechanisms
Type I - lgE - Soluble antigen
 - Allergen-specific lgE antibodies bind
Hypersensitivity ... , seasonal hay fever ... antigen, leading to complement ... Complement activation ... Diagnosis #Reactions #Table
Petechial/Purpuric Rashes- THE ALGORITHMIC APPROACH 

These rashes can be especially challenging and are
associated with devastating differential
Purpuric Rashes- THE ALGORITHMIC ... with devastating differential ... ; however, an algorithmic ... petechiae/purpura with fever ... petechiae/purpura with fever
Skin Conditions Associated with Joint Pain

Rash
	• Human parvovirus B19 infection

Malar rash
	• SLE
	• Human parvovirus B19 infection
	•
• Rheumatic fever ... Palpable purpura • Hypersensitivity ... vasculitis • ... Antiphospholipid-antibody syndrome • Vasculitis ... #skin #rashes #differential
Non-Resolving Pneumonias: Etiologies
Unusual Infections:
 - Immunocompromised patients (e.g.: Mycobacterium, Aspergillosis, Nocardia)
 - Endemic Fungi (e.g.: Histoplasmosis,
yersinia/rats, Q fever ... disorders: - Vasculitis ... - Hypersensitivity ... diagnosis #pulmonary #differential
Purpura - Differential Diagnosis Framework

Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
Purpura - Differential ... : • Hypersensitivity ... • Ig A vasculitis ... mountain spotted fever ... Vasculopathy #Purpura #Differential