Hypocomplementemia complement table algorithm vasculitis huv testing cold anemia hematology

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Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm
Extravascular - Spleen and RES-mediated hemolysis
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Warm AIHA • Cold ... perfringens - Complement-Mediated ... immune-complex hemolytic anemia ... MAHA (TTP, DIC, HUS ... #Causes #Hematology

Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
1. Cold Agglutinins (CAD)
2. Donath-Landsteiner

Cryoglobulins (Vasculitic ... Positive Coombs testing ... Mycoplasma, EBV, HIV ... temperatures by fixing complement ... #hematology #diagnosis

Hemolytic Anemia - Differential Diagnosis Algorithm
• Sickle cells - Consider sickle cell disease (diverse genotypes):

Hemolytic Anemia ... Agglutination - Cold ... cardiac valve, vasculitis ... #workup #hematology ... #testing

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