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diagnosis management rheumatology classification differential crohns gastroenterology table types vasculitis allergy comparison hypersensitivity ibd reactions sle causes champs cryoglobulinemia cryoglobulins
Causes of Hypocomplementemia - CHAMPS Mnemonic C - Cryoglobulinemia (85%), C3 glomerulopathy, cirrhosis H - Heavy Chain deposition
Causes of Hypocomplementemia ... Chain deposition disease ... S - Systemic Lupus ... @AnnKumfer #Hypocomplementemia ... #Low #Complement
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
staining): • Low Complement ... Post-strep GN, Lupus ... Idiopathic • Normal Complement ... involvement: Anti-GBM Disease ... differential #diagnosis #algorithm
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
often involved • Hypocomplementemic ... Urticaria and hypocomplementemia ... inflammation Others: • Lupus ... such as systemic lupus ... against MPO • Complement
Causes of Hematuria - Differential Diagnosis Algorithm Red blood cells on urine microscopy. Must exclude false positives
Differential Diagnosis Algorithm ... • Thin GBM disease ... IgA, post-strep, lupus ... • Pauci-immune disease ... • Lupus glomerulonephritis
Perianal Crohn's Disease - IBD Algorithm • 5-40% w perianal fistula • ↑ risk if colonic
Perianal Crohn's Disease ... - IBD Algorithm ... #IBDAlgorithm # ... IBD #Algorithm # ... gastroenterology #management #treatment
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
Systemic Lupus Erythematosus ... , oral ulcers, Lupus ... 80% - Low complement ... life-threatening • Treatment ... Evolution: Chronic disease
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
90% - Low complement ... constitutional symptoms • Treatment ... 80% - Low complement ... life-threatening • Treatment ... Evolution: Chronic disease
Hypersensitivity Types and Their Mechanisms Type I - lgE - Soluble antigen - Allergen-specific lgE antibodies bind
antigen, leading to complement ... during hemolytic disease ... Complement activation ... Post-streptococcal glomerulonephritis ... , and systemic lupus
Summary table of types of hypersensitivity reactions. Type 1 - Mediators: lgE - Antigen Form: Soluble
antigens, leading to complement ... reaction, Haemolytic disease ... they activate complement ... Post-streptococcal glomerulonephritis ... , Systemic lupus
Algorithm for the Treatment of Membranous Lupus Nephritis Sub-nephrotic-range proteinuria (<3.5g/d, normal serum albumin) and Preserved kidney
Algorithm for the ... Treatment of Membranous ... Lupus Nephritis ... for worsening disease ... #Membranous #Lupus
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