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diagnosis rheumatology differential glomerular glomerulonephritis nephrology nephrotic anemia cryoglobulinemia cryoglobulins disease erythematosus gammopathy hemolytic initial lupus mgrs monoclonal nephritic nephritis
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
often involved • Hypocomplementemic ... Urticaria and hypocomplementemia ... Vasculitis: + MPO-ANCA ... against MPO • Complement ... #classification
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
staining): • Low Complement ... Idiopathic • Normal Complement ... Glomerulonephritis #Vasculitis ... differential #diagnosis #algorithm ... #rheumatology
Recommended initial testing for patients being evaluated for glomerular disease 24-hour urine collection - Quantify proteinuria.
Recommended initial testing ... or alternative complement ... ANCA - Screen for ... ANCA-related vasculitis ... #workup #diagnosis
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
• Low serum C4 complement ... DDX: • ANCA (Antineutrophil ... diagnosis #types #classification ... #rheumatology # ... vasculitis
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Differential Diagnosis Algorithm ... cardiac valve, vasculitis ... Differential #Diagnosis #Algorithm ... #workup #hematology ... #testing
Recommended initial testing for patients being evaluated for glomerular disease 1) 24-hour urine collection - Quantify proteinuria.
Recommended initial testing ... or alternative complement ... disorders. 9) ANCA ... vasculitis. 10 ... glomerular #disease #workup
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
anti-Smith Ab, low complements ... Skin Disease Classification ... vasculitis, rheumatoid ... vein thrombosis Hematologic ... RNP antibodies, Complement
Monoclonal Gammopathy of Renal Significance (MGRS) MGRS • MGRS refers to kidney disease caused by nephrotoxic monoclonal immunoglobulins
meet criteria for hematologic ... Diagnostic Workup ... guide subtype classification ... tubulopathy) - Complement ... formation causing vasculitis
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