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diagnosis rheumatology allergy differential hypersensitivity reactions syndrome table comparison cryoglobulinemia cryoglobulins dermatology erythematosus lupus management oncology pathophysiology sjogrens sle sweet
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
often involved • Hypocomplementemic ... Urticaria and hypocomplementemia ... and branches • GCA ... against MPO • Complement ... #rheumatology #classification
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
activate the immune system ... arthralgia, and arthritis ... • Low serum C4 complement ... disorder (e.g. systemic ... #classification
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
Diagnosis: • Systemic ... Elevated ESR and CRP GCA ... develop in pts with GCA ... Elevated AST ALT • Hypocomplementemia ... ) • Hypocomplementemic
Hypersensitivity Types and Their Mechanisms Type I - lgE - Soluble antigen - Allergen-specific lgE antibodies bind
- Local and systemic ... Complement activation ... glomerulonephritis, rheumatoid arthritis ... , and systemic lupus ... #Classification
Summary table of types of hypersensitivity reactions. Type 1 - Mediators: lgE - Antigen Form: Soluble
antigens, leading to complement ... they activate complement ... Examples: Rheumatoid arthritis ... glomerulonephritis, Systemic ... allergy #table #classification
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... anti-Smith Ab, low complements ... Skin Disease Classification ... Kikuchi disease • Type-I ... RNP antibodies, Complement
Sweet Syndrome Acute febrile neutrophilic dermatosis (Sweets Syndrome) is a skin condition characterized by fever and inflamed
associated with systemic ... Musculoskeletal system ... lymphoma, breast CA ... such as certain types ... Leukocytoclastic vasculitis
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
Cytopenia: 2% • Hypocomplementemia ... IV RTA, TYPE I ... ) • Cutaneous vasculitis ... Vasculitis: • ... Arthralgia and Arthritis
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