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diagnosis rheumatology differential classification signs symptoms cardiology cryoglobulinemia cryoglobulins extraarticular glomerulonephritis headache henochscholeinpurpura hsp huv hypocomplementemic iga management pericarditis progressive
Pathophysiology of Hypocomplementemic Urticarial Vasculitis C1q/anti-C1q antibiody -> Immune Complex Formation - Complement Pathway Activation (C3a and C5a)
Pathophysiology ... of Hypocomplementemic ... Complex Formation - Complement ... TerrierBen #Hypocomplementemic ... #HUV #Pathophysiology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
tract, and often causes ... often involved • Hypocomplementemic ... Urticaria and hypocomplementemia ... Glomerulonephritis, arthritis ... against MPO • Complement
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
three primary pathophysiologic ... causes differentiated ... staining): • Low Complement ... Glomerulonephritis #Vasculitis ... differential #diagnosis #algorithm
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
GCA (Giant Cell Arteritis ... tract, and often causes ... arthritis. ... Elevated AST ALT • Hypocomplementemia ... ) • Hypocomplementemic
Causes of Headache - Differential Diagnosis Algorithm Primary: Tension, Migraine, Cluster Extracranial: Medications, Sinusitis, TMJ disorder, Cervicogenic, Glaucoma,
Causes of Headache ... Differential Diagnosis Algorithm ... Glaucoma, Giant cell arteritis ... Aneurysm, Hemorrhage, Vasculitis ... #algorithm
IgA Vasculitis – Henoch Scholein Purpura: Pathogenesis and Clinical Findings - Infectious Agents - 50% have
IgA Vasculitis – ... Activation of complement ... periumbilical region), nausea ... Arthralgia's (common), arthritis ... HenochScholeinPurpura #Pathophysiology
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
• They can cause ... Cryoglobulins Cause ... arthralgia, and arthritis ... • Low serum C4 complement ... SLE), rheumatoid arthritis
Causes of Pericarditis - Differential Diagnosis Algorithm Viral: • Coxsackie • Echovirus • Adenovirus • Epstein-Barr virus
Causes of Pericarditis ... Differential Diagnosis Algorithm ... • Rheumatoid arthritis ... spondyloarthropathies • Vasculitis ... #Causes #Cardiology
Rheumatoid arthritis (RA): Extra-articular manifestations Skin: • Inflammation of skin (esp. over areas of stress) forms
Rheumatoid arthritis ... blood vessels (vasculitis ... inflammation tends to cause ... RheumatoidArthritis #RA #pathophysiology
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
Cytopenia: 2% • Hypocomplementemia ... • Can cause TYPE ... ) • Cutaneous vasculitis ... : 2% Systemic Vasculitis ... Arthralgia and Arthritis
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