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diagnosis rheumatology classification allergy differential hypersensitivity management reactions table agglutinin anemia cold comparison cryoglobulinemia cryoglobulins disease erythematosus glomerulonephritis hematology hemolytic
Pathophysiology of Hypocomplementemic Urticarial Vasculitis C1q/anti-C1q antibiody -> Immune Complex Formation - Complement Pathway Activation (C3a and C5a)
Pathophysiology ... of Hypocomplementemic ... Complex Formation - Complement ... TerrierBen #Hypocomplementemic ... #HUV #Pathophysiology
Hypersensitivity Types and Their Mechanisms Type I - lgE - Soluble antigen - Allergen-specific lgE antibodies bind
antigen, leading to complement ... Type Ill - IgG and ... Complement activation ... glomerulonephritis, rheumatoid arthritis ... Classification #Pathophysiology
IgA Vasculitis – Henoch Scholein Purpura: Pathogenesis and Clinical Findings - Infectious Agents - 50% have
IgA Vasculitis – ... Activation of complement ... Leukocytoclastic vasculitis ... Arthralgia's (common), arthritis ... #Pathophysiology
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
Cryoglobulins are Igs ... arthralgia, and arthritis ... • Low serum C4 complement ... • IgA vasculitis ... SLE), rheumatoid arthritis
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
Schonlein Purpura (IgA ... and often causes arthritis ... often involved • Hypocomplementemic ... Urticaria and hypocomplementemia ... against MPO • Complement
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
three primary pathophysiologic ... staining): • Low Complement ... : IgA nephropathy ... Glomerulonephritis #Vasculitis ... differential #diagnosis #algorithm
Summary table of types of hypersensitivity reactions. Type 1 - Mediators: lgE - Antigen Form: Soluble
- Mediators: IgG ... / IgM - Antigen ... antigens, leading to complement ... they activate complement ... Examples: Rheumatoid arthritis
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
GCA (Giant Cell Arteritis ... Schonlein Purpura (IgA ... , IgA (cmpkx deposits ... Elevated AST ALT • Hypocomplementemia ... ) • Hypocomplementemic
Type II Hypersensitivity: Pathogenesis and clinical findings Definition: When antigens bind to the body's cell surfaces, forming
Type II Hypersensitivity ... , rarely IgM) against ... activates the complement ... cell surfaces #Type2 ... Allergy #Immunology #pathophysiology
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Agglutinin Disease 3 Types ... Cryoglobulins (Vasculitic ... Idiopathic monoclonal IgM ... Immunoglobulin M (IgM ... temperatures by fixing complement
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