Hypocomplementemia complement vasculitis algorithm testing cold nephrotic nephritic anemia

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Rapidly Progressive Glomerulonephritis (RPGN)
RPGN has three primary pathophysiologic causes differentiated by immunofluorescence

Immune Complex Mediated (granular staining):

staining): • Low Complement ... Post-strep GN, Lupus Nephritis ... Idiopathic • Normal Complement ... Glomerulonephritis #Vasculitis ... differential #diagnosis #algorithm

Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
1. Cold Agglutinins (CAD)
2. Donath-Landsteiner

Cryoglobulins (Vasculitic ... • Symptoms of anemia ... • hemolytic anemia ... Positive Coombs testing ... temperatures by fixing complement

SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and

peritonitis Lupus nephritis ... abnormalities (non-nephrotic ... hematuria) • Frank nephritis ... (nephrotic-range ... suspicion for nephritis

Recommended initial testing for patients being evaluated for glomerular disease

24-hour urine collection - Quantify proteinuria.

Hemolytic Anemia - Differential Diagnosis Algorithm
• Sickle cells - Consider sickle cell disease (diverse genotypes):

Hemolytic Anemia ... Differential Diagnosis Algorithm ... Agglutination - Cold ... cardiac valve, vasculitis ... workup #hematology #testing

Nail Disorders secondary to Systemic Diseases
Nail Fold Abnormality
• SLE
• Scleroderma
• Dermatomyositis
Koilonychia - Spoon-shaped

Diseases Nail Fold ... Iron deficiency anemia ... renal failure • Uremia ... discoloration) • Nephrotic ... Differential #Diagnosis #Algorithm

Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm

Peripheral Smear concerning for malignancy?

Differential Diagnosis Algorithm ... hemolysis, deficiency anemia ... Rheumatologic, Vasculitides ... disease, Kawasaki, Nephrotic ... Differential #Diagnosis #Algorithm

Recommended initial testing for patients being evaluated for glomerular disease
1) 24-hour urine collection - Quantify proteinuria.

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