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diagnosis differential nephrology aki acute rheumatology injury renal workup classification disease hematuria kidneyinjury nephrotic management pulmonary syndrome testing urology acuteglomerulonephritis
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
tract, and often causes ... - Skin, glomeruli ... : glomerular ischemia ... Kidneys -> glomerulonephritis ... against MPO • Complement
Causes of Hematuria - Glomerular vs Non-glomerular == Glomerular == - Glomerulonephritis - Thin basement membrane disease ==
Causes of Hematuria ... == - Glomerulonephritis ... == Kidney - ... - Polycystic kidney ... #Algorithm #Diagnosis
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
pathophysiologic causes ... staining): • Low Complement ... • Limited to Kidney ... #Vasculitis #differential ... #diagnosis #algorithm
Causes of Hypocomplementemia - CHAMPS Mnemonic C - Cryoglobulinemia (85%), C3 glomerulopathy, cirrhosis H - Heavy Chain deposition
Causes of Hypocomplementemia ... Membranoproliferative glomerulonephritis ... Post/pauci immune glomerulonephritis ... @AnnKumfer #Hypocomplementemia ... #Low #Complement
Acute Kidney Injury - Classification Prerenal: • Dehydration • Heart failure (a.k.a. cardiorenal syndrome) • Liver failure
Acute Kidney Injury ... - Small vessel vasculitis ... - TTP/HUS • Glomerular ... Post-infectious glomerulonephritis ... tubular necrosis (causes
Membranoproliferative Glomerulonephritis (MPGN) AKA: Mesangiocapillary GN • Active Urine Sediment (dysmorphic RBC, RBC casts, +/- proteinuria)
Membranoproliferative Glomerulonephritis ... dysmorphic RBC, RBC casts ... formation along glomerular ... MGPN • Complement ... Membranoproliferative #Glomerulonephritis
Causes of Hematuria - Differential Diagnosis Algorithm Red blood cells on urine microscopy. Must exclude false positives
Causes of Hematuria ... Differential Diagnosis Algorithm ... • Calculi Glomerular ... Differential #Diagnosis #Algorithm ... #Causes
Causes of Acute Kidney Injury - Differential Diagnosis Framework Pre-Renal Post-Renal Intrinsic Renal: • Tubules (ATN) • Glomerular:
Causes of Acute ... Kidney Injury - ... Tubules (ATN) • Glomerular ... #KidneyInjury #Causes ... Differential #Diagnosis #Algorithm
Causes of Acute Kidney Injury ( AKI ) - Prerenal, Renal, and Postrenal PRE-RENAL Impaired perfusion: •
Causes of Acute ... Kidney Injury ( ... occlusion RENAL Glomerulonephritis ... Small-vessel vasculitis ... Diagnosis #Acute #Kidney
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
musculoskeletal systems • Kidneys ... : Non-glomerular ... tract, and often causes ... Elevated AST ALT • Hypocomplementemia ... ) • Hypocomplementemic
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