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diagnosis differential rheumatology acute aki dermatology injury kidney nephrology anca cryofibrinogenemia cryoglobulinemia ddxof erythematosus gammopathy glomerulonephritis hematology henochscholeinpurpura hsp iga
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
• They can cause ... Cause Organ Damage ... • Low serum C4 complement ... • Cutaneous small-vessel ... diagnosis #types #classification
A System for Vasculitides #Diagnosis #IM #Rheum #Vasculitis #Small #Medium #Large #Vessel #Size #Classification #ANCA #Differential
A System for Vasculitides ... Diagnosis #IM #Rheum #Vasculitis ... #Small #Medium ... #Vessel #Size #Classification ... #Differential #Algorithm
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
abnormalities SMALL ... tract, and often causes ... against MPO • Complement ... Serologies for Cryoglobulins ... #rheumatology #classification
Causes of Purpura - Differential Diagnosis Non-PalpabIe → Palpable • Thrombocytopenia (HIT, ITP/HUS), Coagulation defects (DIC, warfarin
Causes of Purpura ... Leukocytoclastic Vasculitis ... complex mediated (cryoglobulins ... ANCA associated small ... nonpalpable #palpable #Causes
Vascular Skin Lesions - Differential Diagnosis Algorithm - Petechiae < 0.2 cm diameter - Purpura 0.2
Differential Diagnosis Algorithm ... with Pressure - Small ... • Acquired - Vasculitis ... #Vascular #Vasculitis ... #causes
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
pathophysiologic causes ... staining): • Low Complement ... Idiopathic • Normal Complement ... Glomerulonephritis #Vasculitis ... differential #diagnosis #algorithm
Cryofibrinogenemia Summary Cryofibrinogenemia Epidemiology: • 40-70 years with a modest female predominance Cryofibrinogenemia: • The precipitation of a
, fibronectin, small ... • Cryoglobulins ... malignancies, vasculitis ... • Negative causes ... : Occlusion of small
Acute Kidney Injury - Classification Prerenal: • Dehydration • Heart failure (a.k.a. cardiorenal syndrome) • Liver failure
Kidney Injury - Classification ... emergency - Small ... vessel vasculitis ... tubular necrosis (causes ... Kidney #Injury #Classification
IgA Vasculitis – Henoch Scholein Purpura: Pathogenesis and Clinical Findings - Infectious Agents - 50% have
IgA Vasculitis – ... Activation of complement ... histopathologic term for small ... - Cutaneous small ... periumbilical region), nausea
Causes of Petechial Rash - Differential Diagnosis Algorithm Pinpoint areas (less than 2 mm) of hemorrhage, which
Causes of Petechial ... Differential Diagnosis Algorithm ... Infection - Vasculitis ... immunoglobulins & cryoglobulins ... #Causes #dermatology
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