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diagnosis differential rheumatology nonpalpable palpable purpura cryoglobulinemia cryoglobulins ddxof dermatology erythematosus glomerulonephritis hematology henochscholeinpurpura hsp im large lupus medium pathophysiology
A System for Vasculitides #Diagnosis #IM #Rheum #Vasculitis #Small #Medium #Large #Vessel #Size #Classification #ANCA #Differential
A System for Vasculitides ... #Small #Medium ... #Vessel #Size #Classification ... #ANCA #Differential ... #Algorithm #Ddxof
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
abnormalities SMALL ... Schonlein Purpura (IgA ... tract, and often causes ... against MPO • Complement ... #rheumatology #classification
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
pathophysiologic causes ... staining): • Low Complement ... : IgA nephropathy ... Glomerulonephritis #Vasculitis ... differential #diagnosis #algorithm
IgA Vasculitis – Henoch Scholein Purpura: Pathogenesis and Clinical Findings - Infectious Agents - 50% have
IgA Vasculitis – ... Activation of complement ... histopathologic term for small ... - Cutaneous small ... periumbilical region), nausea
Causes of Purpura - Differential Diagnosis Non-PalpabIe → Palpable • Thrombocytopenia (HIT, ITP/HUS), Coagulation defects (DIC, warfarin
Causes of Purpura ... Leukocytoclastic Vasculitis ... cryoglobulins, IgA ... ), ANCA associated ... small vessel
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
and infarcts SMALL ... Schonlein Purpura (IgA ... tract, and often causes ... Elevated AST ALT • Hypocomplementemia ... ) • Hypocomplementemic
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
• Low serum C4 complement ... DDX: • ANCA (Antineutrophil ... • IgA vasculitis ... • Cutaneous small-vessel ... diagnosis #types #classification
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
disorders, or other causes ... • Secondary Causes ... • Ig A vasculitis ... Cryoglobulinemia (MIXED) • ANCA ... associated small
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
anti-Smith Ab, low complements ... Skin Disease Classification ... vasculitis, rheumatoid ... inflammation of the small ... RNP antibodies, Complement
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