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diagnosis rheumatology biopsy cryoglobulinemia cryoglobulins differential disease erythematosus gammopathy lupus mgus monoclonal multiplemyeloma phenotypes related sjogrens sle syndrome systemic treatment
IgG4-Related Disease Clinical history: Man, 60 years, multiorgan involvement, unique or multiple inflammatory pseudotumor 4 phenotypes: •
false negative (small ... rheumatoid factor), ± hypocomplementemia ... No necrosis, No vasculitis ... Disease #diagnosis #management ... workup #treatment #rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
abnormalities SMALL ... Urticaria and hypocomplementemia ... pain, infarct • Small ... against MPO • Complement ... #classification
IGG-4 RELATED DISEASE WHAT? • A chronic, immune-mediated fibroinflammatory disease with tumefactive infiltration of IgG4+ plasma cells
aortitis, mimics vasculitis ... - ↑ IgE, ↓ complement ... • Classification ... mimics excluded MANAGEMENT ... #Management #Rheumatology
Suggested algorithm for bone marrow biopsy and skeletal imaging in patients with monoclonal gammopathy of undetermined
Suggested algorithm ... patients with small ... low-risk MGUS (IgG ... #diagnosis #management ... #hematology #multiplemyeloma
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
• Low serum C4 complement ... • Cutaneous small-vessel ... diagnosis #types #classification ... #rheumatology # ... vasculitis
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
anti-Smith Ab, low complements ... Skin Disease Classification ... Malignancy (e.g. hematologic ... inflammation of the small ... RNP antibodies, Complement
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
Cytopenia: 2% • Hypocomplementemia ... nervous system: small-fiber ... ) • Cutaneous vasculitis ... Nephrogenic DI Hematologic ... #Diagnosis #Management
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