17 results
Causes of Hypocomplementemia - CHAMPS Mnemonic
C - Cryoglobulinemia (85%), C3 glomerulopathy, cirrhosis
H - Heavy Chain deposition
Causes of Hypocomplementemia ... , type 1 (50%-80% ... ), type II (80-90% ... @AnnKumfer #Hypocomplementemia ... #Low #Complement
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
- Skin, glomeruli ... Urticaria and hypocomplementemia ... : - Kidneys: glomerular ... against MPO • Complement ... #rheumatology #classification
Rapidly Progressive Glomerulonephritis (RPGN) 
 - Loss of kidney function over a short period of tirne
Rapidly Progressive Glomerulonephritis ... with evidence of glomerular ... autoAb against type ... staining #Glomerulonephritis ... #RPGN #Classification
Cryoglobulinemia Summary

Cryoglobulins:
 • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
Skin ulcers - Glomerulonephritis ... Types: • Type ... • Low serum C4 complement ... • Vasculitis ... #classification
Recommended initial testing for patients being evaluated for glomerular disease 

24-hour urine collection - Quantify proteinuria.
Recommended initial testing ... or alternative complement ... for ANCA-related vasculitis ... cryoglobulinemias (types ... #diagnosis #glomerulonephritis
Hypersensitivity Types and Their Mechanisms
Type I - lgE - Soluble antigen
 - Allergen-specific lgE antibodies bind
Hypersensitivity Types ... antigen, leading to complement ... Complement activation ... Post-streptococcal glomerulonephritis ... #Classification
Vasculitis - Break down based on vessel size 
Distribution of vessel involvement by large vessel vasculitis,
Vasculitis - Break ... by large vessel vasculitis ... can affect any type ... Anti-GBM = anti–glomerular ... Medium #Large #Classification
Acute Kidney Injury - Classification
Prerenal:
 • Dehydration
 • Heart failure (a.k.a. cardiorenal syndrome)
 • Liver failure
Kidney Injury - Classification ... - Small vessel vasculitis ... - TTP/HUS • Glomerular ... Post-infectious glomerulonephritis ... Kidney #Injury #Classification
Summary table of types of hypersensitivity reactions. 
Type 1
 - Mediators: lgE
 - Antigen Form: Soluble
Summary table of types ... antigens, leading to complement ... they activate complement ... Post-streptococcal glomerulonephritis ... allergy #table #classification
Pulmonary Renal Syndrome

Definition: Diffuse alveolar hemorrhage + Glomerulonephritis
Presentation (Pulmonary and renal manifestations can occur weeks apart):
alveolar hemorrhage + Glomerulonephritis ... ANCA-positive vasculitis ... ANCA-negative vasculitis ... sclerosis • Anti-Glomerular ... Disease-specific testing