Rapidly Progressive Glomerulonephritis (RPGN) - Loss of kidney function over a short period of tirne - Urinalysis with evidence of glomerular disease (hematuria, proteinuria) - Crescent formation (extra-capillary proliferation in Bowman's space) Immune-Complex Mediated • Presence of immune deposits in glomeruli • Ex: IgA nephropathy, lupus nephritis, cryoglobulinemia, post-infectious GN Anti-Glomerular Basement Membrane (GBM) • Typically circulating autoAb against type IV collagen (alpha3 chain) • Linear, ribbon-like GBM staining on IF • No EM deposits Pauci-lmmune • Minimal immune deposits, negative IF • Majority anti-neutrophil cytoplasmic antibody (ANCA) + • c-ANCA: anti-proteinase 3 (CPR) cytoplasmic neutrophilic staining • p-ANCA: anti-myeloperioxidase (MPO) perinuclear cytoplasmic staining #Glomerulonephritis #RPGN #Classification #Differential #Diagnosis #Nephrology
