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diagnosis rheumatology differential types allergy clinicopathology comparison cryoglobulinemia cryoglobulins gammopathy gi glomerulonephritis hypersensitivity igg4 ileitis laboratory management mgrs monoclonal rapidly
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
Rapidly Progressive ... pathophysiologic causes ... staining): • Low Complement ... Glomerulonephritis #Vasculitis ... differential #diagnosis #algorithm
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
proteinuria, rapidly progressing ... tract, and often causes ... Urticaria and hypocomplementemia ... against MPO • Complement ... #rheumatology #classification
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
proteinuria, Rapidly progressing ... is 50 years • Progressive ... tract, and often causes ... Elevated AST ALT • Hypocomplementemia ... ) • Hypocomplementemic
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
• They can cause ... Cryoglobulins Cause ... • Low serum C4 complement ... • Vasculitis ... diagnosis #types #classification
Causes of ileitis beyond Crohn’s disease and infections include systemic disorders -spondyloarthropathies, vasculitides, ischemia, and amyloidosis
Causes of ileitis ... spondyloarthropathies, vasculitides ... See below for table ... helpful paper complements ... #Differential #Table
Summary table of types of hypersensitivity reactions. Type 1 - Mediators: lgE - Antigen Form: Soluble
Summary table of ... Allergen-specific lgE causes ... they activate complement ... types #allergy #table ... #classification
IGG-4 RELATED DISEASE WHAT? • A chronic, immune-mediated fibroinflammatory disease with tumefactive infiltration of IgG4+ plasma cells
inflammation -> progressive ... aortitis, mimics vasculitis ... - ↑ IgE, ↓ complement ... • Classification
Monoclonal Gammopathy of Renal Significance (MGRS) MGRS • MGRS refers to kidney disease caused by nephrotoxic monoclonal immunoglobulins
kidney disease caused ... guide subtype classification ... tubulopathy) - Complement ... formation causing vasculitis ... function and prevent progression
6/02/2022 UPDATE: This assay is designed to detect non-variola orthopoxviruses, including monkeypox virus. It is not
2022-lab-advisory-CLARIFICATION-CDC_Publishes_Non-variola_Orthopoxvirus_PCR_Testing_Procedure ... should use this algorithm ... smallpox-diagnostic-algorithm-poster ... depending upon disease progression ... See table below
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