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diagnosis differential rheumatology glomerular glomerulonephritis nephrology nephrotic testing classification comparison druginduced gammopathy hypertension ileitis indications initial lupus management mgrs monoclonal
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
tract, and often causes ... often involved • Hypocomplementemic ... Urticaria and hypocomplementemia ... neuropathy - GI ... against MPO • Complement
Causes of ileitis beyond Crohn’s disease and infections include systemic disorders -spondyloarthropathies, vasculitides, ischemia, and amyloidosis
Causes of ileitis ... beyond Crohn’s disease ... spondyloarthropathies, vasculitides ... See below for table ... helpful paper complements
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
pathophysiologic causes ... staining): • Low Complement ... involvement: Anti-GBM Disease ... Glomerulonephritis #Vasculitis ... differential #diagnosis #algorithm
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
atherosclerotic disease ... mononeuritis multiplex • GI ... tract, and often causes ... Elevated AST ALT • Hypocomplementemia ... ) • Hypocomplementemic
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
• Immunologic Workup ... 90% - Low complement ... • Immunologic Workup ... Evolution: Chronic disease ... sle #comparison #table
Causes of Secondary Hypertension - Workup and Differential Diagnosis Approach (when evaluation should be done): 1. Severe or
Hypertension - Workup ... with previously stable ... Coarctation of aorta, Vasculitis ... Renal parenchymal disease ... #Hypertension #Workup
Recommended initial testing for patients being evaluated for glomerular disease 24-hour urine collection - Quantify proteinuria.
for glomerular disease ... or alternative complement ... infections are common causes ... for ANCA-related vasculitis ... glomerular #testing #workup
Recommended initial testing for patients being evaluated for glomerular disease 1) 24-hour urine collection - Quantify proteinuria.
for glomerular disease ... or alternative complement ... infections are common causes ... for ANCA-related vasculitis ... #workup #diagnosis
Monoclonal Gammopathy of Renal Significance (MGRS) MGRS • MGRS refers to kidney disease caused by nephrotoxic monoclonal immunoglobulins
caused by nephrotoxic ... Clinical Clues: ... Diagnostic Workup ... tubulopathy) - Complement ... formation causing vasculitis
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