14 results
Pathophysiology of Hypocomplementemic Urticarial Vasculitis

C1q/anti-C1q antibiody ->
Immune Complex Formation - Complement Pathway Activation (C3a and C5a)
Pathophysiology ... of Hypocomplementemic ... Complex Formation - Complement ... TerrierBen #Hypocomplementemic ... #HUV #Pathophysiology
IgA Vasculitis – Henoch Scholein Purpura: Pathogenesis and Clinical Findings

 - Infectious Agents - 50% have
IgA Vasculitis – ... Activation of complement ... Leukocytoclastic vasculitis ... periumbilical region), nausea ... #Pathophysiology
Rapidly Progressive Glomerulonephritis (RPGN)
RPGN has three primary pathophysiologic causes differentiated by immunofluorescence

Immune Complex Mediated (granular staining):
three primary pathophysiologic ... causes differentiated ... : IgA nephropathy ... Glomerulonephritis #Vasculitis ... differential #diagnosis #algorithm
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
Schonlein Purpura (IgA ... tract, and often causes ... often involved • Hypocomplementemic ... Urticaria and hypocomplementemia ... against MPO • Complement
Hypersensitivity Types and Their Mechanisms
Type I - lgE - Soluble antigen
 - Allergen-specific lgE antibodies bind
or IgM antibody ... antigen, leading to complement ... Complement activation ... Classification #Pathophysiology ... Diagnosis #Reactions #Table
Cryoglobulinemia Summary

Cryoglobulins:
 • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
Cryoglobulins are Igs ... • They can cause ... Cryoglobulins Cause ... • Low serum C4 complement ... • IgA vasculitis
Vasculitis - Differential Diagnosis Framework

When to Consider Vasculitis:
• Purpura, ischemic skin lesions
• Mononeuritis multiplex
• Hematuria, proteinuria,
Schonlein Purpura (IgA ... tract, and often causes ... , IgA (cmpkx deposits ... Elevated AST ALT • Hypocomplementemia ... ) • Hypocomplementemic
Summary table of types of hypersensitivity reactions. 
Type 1
 - Mediators: lgE
 - Antigen Form: Soluble
Summary table of ... Allergen-specific lgE causes ... antigens, leading to complement ... they activate complement ... types #allergy #table
Causes of ileitis beyond Crohn’s disease and infections include systemic disorders -spondyloarthropathies, vasculitides, ischemia, and amyloidosis
Causes of ileitis ... spondyloarthropathies, vasculitides ... See below for table ... helpful paper complements ... #Differential #Table
Gonorrhea: Pathophysiology

 - Neonatal Transmission -> Direct contact of patient mucosa with mother's infected mucosa while
Gonorrhea: Pathophysiology ... antibodies and causes ... activation of complement ... - Secretion of IgA ... #Gonorrhea #Pathophysiology