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management rheumatology hematology allergy differential hypersensitivity reactions allergic biopsy champs clinicopathology complement complications cryoglobulinemia ddxof definitions diabetes disease dm2 dmii
Causes of Hypocomplementemia - CHAMPS Mnemonic C - Cryoglobulinemia (85%), C3 glomerulopathy, cirrhosis H - Heavy Chain deposition
Causes of Hypocomplementemia ... glomerulonephritis, type ... 1 (50%-80%), type ... @AnnKumfer #Hypocomplementemia ... CHAMPS #Mnemonic #diagnosis
IgG4-Related Disease Clinical history: Man, 60 years, multiorgan involvement, unique or multiple inflammatory pseudotumor 4 phenotypes: •
pseudotumor 4 phenotypes ... PET-CT Imaging (→ Diagnostic ... rheumatoid factor), ± hypocomplementemia ... Related #Disease #diagnosis ... #management #phenotypes
Cryoglobulinemia Classification Types Type 1: Monoclonal IgM (rarely IgG/lgA) • Raynaud phenomenon, Digital ulcers/gangrene, Livedo reticularis, Hyperviscosity
Cryoglobulinemia Classification ... and polyclonal IgG ... and polyclonal IgG ... Cryoglobulinemia #Classification ... #diagnosis
Types of hypersensitivity reactions Type I - lgE-Mediated, Within I Hour (Anaphylaxis) Type II - IgG or IgM
reactions Type ... (Anaphylaxis) Type ... II - IgG or IgM ... #Classification ... #Allergy #Diagnosis
Lupus Nephritis Classification Algorithm #Lupus #Nephritis #Classification #Algorithm #diagnosis #differential #types #rheumatology #nephrology #renal
Lupus Nephritis Classification ... Algorithm #Lupus ... #Nephritis #Classification ... #Algorithm #diagnosis ... #differential #types
Hypersensitivity Types and Their Mechanisms Type I - lgE - Soluble antigen - Allergen-specific lgE antibodies bind
II - IgG or IgM ... IgG can also mediate ... Type Ill - IgG and ... #Classification ... Pathophysiology #Allergy #Diagnosis
Hypersensitivity: Summary Type I Hypersensitivity: • Immunological Mediator: lgE • Immunological Target: Allergen Molecules • Ex: Antibiotic
conjunctivitis Type ... Mediator: IgM + IgG ... Immunological Mediator: IgG ... #Classification ... #Diagnosis #Definitions
Subtypes of Serum Proteins Pre-albumin (Transthyretin) Albumin Globulins • Alpha-1: Alpha-1 antitrypsin, Serum amyloid A, Ceruloplasmin, Corticosteroid-binding globulin (Transcortin),
• Gamma: IgM, IgG ... Proteins #Subtypes #algorithm ... #classification ... #Types #hematology
IGG-4 RELATED DISEASE WHAT? • A chronic, immune-mediated fibroinflammatory disease with tumefactive infiltration of IgG4+ plasma cells
IGG-4 RELATED DISEASE ... • Pancreas: Type ... breast, skin DIAGNOSIS ... complement • Classification ... -4 #IGG4 #Diagnosis
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
- Differential Diagnosis ... often involved • Hypocomplementemic ... Urticaria and hypocomplementemia ... Differential Diagnosis ... #rheumatology #classification
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