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differential rheumatology hematology vasculitis alkaline allergy alp c1inh champs classification deficiency elevation extravascular fever glomerulonephritis hemolysis hepatology immunecompromised immunocompromised inhibitor
Causes of Hypocomplementemia - CHAMPS Mnemonic C - Cryoglobulinemia (85%), C3 glomerulopathy, cirrhosis H - Heavy Chain deposition
Causes of Hypocomplementemia ... @AnnKumfer #Hypocomplementemia ... #Low #Complement ... CHAMPS #Mnemonic #diagnosis
Complement 1 esterase inhibitor (C1-INH) Deficiency Testing Algorithm INDICATIONS FOR TESTING: • Recurrent angioedema (without urticaria) •
Complement 1 esterase ... Deficiency Testing Algorithm ... ARUPLabs #C1INH #Complement ... #esterase #inhibitor ... #allergy #diagnosis
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
pathophysiologic causes ... staining): • Low Complement ... Idiopathic • Normal Complement ... #differential #diagnosis ... #algorithm #rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
- Differential Diagnosis ... tract, and often causes ... often involved • Hypocomplementemic ... Urticaria and hypocomplementemia ... against MPO • Complement
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm Extravascular - Spleen and RES-mediated hemolysis -
Causes of Extravascular ... - Differential Diagnosis ... Algorithm Extravascular ... perfringens - Complement-Mediated ... #Algorithm #Causes
Alkaline Phosphatase (ALP) Elevation - Differential Diagnosis Algorithm ALP: - Enzymes that catalyze hydrolysis of organic phosphate
- Differential Diagnosis ... Algorithm ALP ... organic phosphate esters ... Intestine - Other causes ... #Algorithm #hepatology
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
- Differential Diagnosis ... Vasculitis Differential Diagnosis ... tract, and often causes ... Elevated AST ALT • Hypocomplementemia ... Vasculitis) • Hypocomplementemic
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
Sjogren's Syndrome Diagnosis ... Cytopenia: 2% • Hypocomplementemia ... • Can cause TYPE ... RTA, TYPE I RTA Diagnosis ... #Rheumatology #Diagnosis
Causes of Fever in the Immunocompromised Host - Differential Diagnosis Algorithm Structural Defect - Asplenia/HypospIenism • Bacteremia/Septic
Causes of Fever ... - Differential Diagnosis ... Algorithm Structural ... Periodontal Disease Complement ... #Algorithm #Causes
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