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diagnosis differential rheumatology vasculitis antibiotics febrile hematology infant management pediatrics peds risk stepbystep stratification agglutinin anemia champs classification cold comparison
Causes of Hypocomplementemia - CHAMPS Mnemonic C - Cryoglobulinemia (85%), C3 glomerulopathy, cirrhosis H - Heavy Chain deposition
Causes of Hypocomplementemia ... @AnnKumfer #Hypocomplementemia ... #Low #Complement
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
often involved • Hypocomplementemic ... Urticaria and hypocomplementemia ... Vasculitis: • Fevers ... against MPO • Complement ... (Low levels mixed
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
staining): • Low ... Complement: Post-strep ... Idiopathic • Normal Complement ... to Kidney: Anti-GBM ... differential #diagnosis #algorithm
“Step by Step” – the new kid on the block – aims to risk stratify this
components of the algorithm ... be considered “low ... an infant with fever ... #LP #Antibiotics ... Stratification #Fever
Pulmonary Renal Syndromes and Mimics - Differential Diagnosis Framework Diffuse alveolar hemorrhage + rapidly progressive glomerulonephritis 90%: -
Vasculitis - Anti-GBM ... Positive (ANCA + anti-GBM ... ) 10%: - Low Complement ... Vasculitis - Normal Complement ... other hemorrhagic fevers
Comparison of Fever Algorithms for Infants <3 months old AGE, INCLUSION, TESTS REQUIRED, "LOW RISK" CRITERIA, TREATMENT,
Comparison of Fever ... Algorithms for ... TESTS REQUIRED, "LOW ... criteria #EBM ... #Fever #Algorithm
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
Vasculitis: • Fevers ... and branches • Fever ... pain and GN Anti-GBM ... Elevated AST ALT • Hypocomplementemia ... Vasculitis) • Hypocomplementemic
The Febrile Infant Step-by-Step Algorithm This is an algorithm developed by European emergency physicians to identify low-risk
This is an algorithm ... physicians to identify low-risk ... 46.9% #Diagnosis #EBM ... #LP #Antibiotics ... Stratification #Fever
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
originate from a low-grade ... - Mycoplasma, EBV ... temperatures by fixing complement ... Symptoms: High fevers
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