6 results
Pathophysiology of Hypocomplementemic Urticarial Vasculitis

C1q/anti-C1q antibiody ->
Immune Complex Formation - Complement Pathway Activation (C3a and C5a)
Pathophysiology ... of Hypocomplementemic ... Urticarial Vasculitis ... Complex Formation - Complement ... TerrierBen #Hypocomplementemic
Type I Hypersensitivity: Pathogenesis and clinical findings
Definition: Production of lgE Antibodies that bind to harmless allergens
leading to an allergic ... Sensitization" to Allergen ... peanuts) • Hay fever ... pollen & dust) • Urticaria ... #Immunology #pathophysiology
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
often involved • Hypocomplementemic ... and hypocomplementemia ... Coronary arteries - Fever ... Vasculitis: • Fevers ... against MPO • Complement
Hypersensitivity Types and Their Mechanisms
Type I - lgE - Soluble antigen
 - Allergen-specific lgE antibodies bind
When the specific allergen ... , seasonal hay fever ... antigen, leading to complement ... Complement activation ... Classification #Pathophysiology
Complement 1 esterase inhibitor (C1-INH) Deficiency Testing Algorithm
INDICATIONS FOR TESTING:
 • Recurrent angioedema (without urticaria)
 •
Complement 1 esterase ... Deficiency Testing Algorithm ... angioedema (without urticaria ... ARUPLabs #C1INH #Complement ... #allergy #diagnosis
Vasculitis - Differential Diagnosis Framework

When to Consider Vasculitis:
• Purpura, ischemic skin lesions
• Mononeuritis multiplex
• Hematuria, proteinuria,
Vasculitis: • Fevers ... and branches • Fever ... Elevated AST ALT • Hypocomplementemia ... Vasculitis) • Hypocomplementemic ... Urticarial Vasculitis