11 results
Pathophysiology of Hypocomplementemic Urticarial Vasculitis

C1q/anti-C1q antibiody ->
Immune Complex Formation - Complement Pathway Activation (C3a and C5a)
Pathophysiology of Hypocomplementemic ... Complex Formation - Complement ... TerrierBen #Hypocomplementemic ... Urticarial #Vasculitis #HUV
Causes of Hypocomplementemia - CHAMPS Mnemonic
C - Cryoglobulinemia (85%), C3 glomerulopathy, cirrhosis
H - Heavy Chain deposition
Causes of Hypocomplementemia ... A - Atypical HUS ... @AnnKumfer #Hypocomplementemia ... #Low #Complement
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
often involved • Hypocomplementemic ... Urticaria and hypocomplementemia ... against MPO • Complement ... (Low levels mixed ... #rheumatology #classification
Complement Deficiency Testing Algorithm
 • Normal CH50 and AH50 AND High suspicion for complement deficiency
 •
Complement Deficiency ... Testing Algorithm ... deficiency • Low ... #Deficiency #Testing ... #Algorithm #hematology
Cryoglobulinemia Summary

Cryoglobulins:
 • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
• Infections: HCV ... infection, HBV ... factor level • Low ... serum C4 complement ... diagnosis #types #classification
Recommended initial testing for patients being evaluated for glomerular disease 

24-hour urine collection - Quantify proteinuria.
Recommended initial testing ... in monitoring low-level ... or alternative complement ... antibody, and HIV ... #glomerular #testing
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
originate from a low-grade ... Positive Coombs testing ... post infectious setting ... Mycoplasma, EBV, HIV ... temperatures by fixing complement
Recommended initial testing for patients being evaluated for glomerular disease
1) 24-hour urine collection - Quantify proteinuria.
Recommended initial testing ... in monitoring low-level ... or alternative complement ... antibody, and HIV ... diagnosis #initial #testing
Nontuberculous Mycobacteria (NTM) Infections 

Mycobacterial species other than those belonging to the Mycobacterium tuberculosis complex and
Slow Growers (Runyon ... Classification ... Growers (Runyon Classification ... haemophilum • Tropical setting ... Advanced HIV (CD4
6/02/2022 UPDATE: This assay is designed to detect non-variola orthopoxviruses, including monkeypox virus. It is not
2022-lab-advisory-CLARIFICATION-CDC_Publishes_Non-variola_Orthopoxvirus_PCR_Testing_Procedure ... should use this algorithm ... risk of smallpox –low ... smallpox-diagnostic-algorithm-poster ... specimens from low