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diagnosis hematology differential workup anemia blood disease glomerular management nephrology nephrotic product reactions agglutinin causes champs classification cold extravascular glomerulonephritis
Causes of Hypocomplementemia - CHAMPS Mnemonic C - Cryoglobulinemia (85%), C3 glomerulopathy, cirrhosis H - Heavy Chain deposition
Causes of Hypocomplementemia ... A - Atypical HUS ... @AnnKumfer #Hypocomplementemia ... #Low #Complement
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm Extravascular - Spleen and RES-mediated hemolysis -
Differential Diagnosis Algorithm ... Defects • G6PD deficiency ... • PK deficiency ... perfringens - Complement-Mediated ... MAHA (TTP, DIC, HUS
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... Differential Diagnosis Algorithm ... DIC, TTP, HELLP, HUS ... Differential #Diagnosis #Algorithm ... workup #hematology #testing
Complement Deficiency Testing Algorithm • Normal CH50 and AH50 AND High suspicion for complement deficiency •
Complement Deficiency ... Testing Algorithm ... deficiency • Low ... #Deficiency #Testing ... #Algorithm #hematology
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
originate from a low-grade ... Positive Coombs testing ... post infectious setting ... Mycoplasma, EBV, HIV ... temperatures by fixing complement
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
often involved • Hypocomplementemic ... Urticaria and hypocomplementemia ... against MPO • Complement ... (Low levels mixed ... • HBV HCV •
Blood Transfusion Reactions Immune Mediated: • Febrile Non-Hemolytic Transfusion Reaction (FNHTR): Most common immune reaction to transfusion.
recipients w/ IgA deficiency ... Hypothermia: Due to low ... false negatives on testing ... 2,000,000,000, HBV ... in 100,000,000, HCV
Blood Product Transfusions One Pager Summary Type and screen - determines blood type and detects in recipient
Crossmatch - involves testing ... recipients w/ IgA deficiency ... Hypothermia: Due to low ... false negatives on testing ... 2,000,000,000, HBV
Recommended initial testing for patients being evaluated for glomerular disease 24-hour urine collection - Quantify proteinuria.
Recommended initial testing ... in monitoring low-level ... LDH - Assess for hemolysis ... or alternative complement ... #glomerular #testing
Recommended initial testing for patients being evaluated for glomerular disease 1) 24-hour urine collection - Quantify proteinuria.
Recommended initial testing ... in monitoring low-level ... LDH - Assess for hemolysis ... or alternative complement ... diagnosis #initial #testing
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