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diagnosis differential nephrology rheumatology glomerular glomerulonephritis nephrotic vasculitis syndrome workup champs classification hematology initial low management membranoproliferative mnemonic mpgn nephritis
Causes of Hypocomplementemia - CHAMPS Mnemonic C - Cryoglobulinemia (85%), C3 glomerulopathy, cirrhosis H - Heavy Chain deposition
Causes of Hypocomplementemia ... Chain deposition disease ... A - Atypical HUS ... @AnnKumfer #Hypocomplementemia ... #Low #Complement
Membranoproliferative Glomerulonephritis (MPGN) AKA: Mesangiocapillary GN • Active Urine Sediment (dysmorphic RBC, RBC casts, +/- proteinuria)
dysmorphic RBC, RBC casts ... ) • Ex: HCV, HBV ... MGPN • Complement ... (Dense deposit disease ... glomerulopathy, radiation nephritis
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
pathophysiologic causes ... staining): • Low Complement ... Post-strep GN, Lupus Nephritis ... involvement: Anti-GBM Disease ... differential #diagnosis #algorithm
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
tract, and often causes ... often involved • Hypocomplementemic ... Urticaria and hypocomplementemia ... against MPO • Complement ... • HBV HCV •
Recommended initial testing for patients being evaluated for glomerular disease 24-hour urine collection - Quantify proteinuria.
Recommended initial testing ... for glomerular disease ... or alternative complement ... infections are common causes ... of glomerular disease
Algorithm - Approach to the differential diagnosis of the patient presenting with overt glomerular proteinuria. CMV
Algorithm - Approach ... impairment), heart disease ... Nephrocalcinosis causes ... #Algorithm #differential ... #proteinuria #nephrotic
Recommended initial testing for patients being evaluated for glomerular disease 1) 24-hour urine collection - Quantify proteinuria.
Recommended initial testing ... or alternative complement ... infections are common causes ... #nephrology #nephrotic ... #nephritis
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
atherosclerotic disease ... HTN • Check: HBV ... tract, and often causes ... Elevated AST ALT • Hypocomplementemia ... Vasculitis) • Hypocomplementemic
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
multisystemic disease ... Cytopenia: 2% • Hypocomplementemia ... • Can cause TYPE ... Xerostomia • Dental caries ... • Interstitial nephritis
Weight Loss - Differential Diagnosis Algorithm Decreased Intake: • GI illness (upper and lower) • Psychiatric (Depression,
Differential Diagnosis Algorithm ... Psychiatric (Depression, eating ... Diabetes Mellitus • HIV ... Differential #Diagnosis #Algorithm ... #Causes
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