5 results
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm
Extravascular - Spleen and RES-mediated hemolysis
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Causes of Extravascular ... Warm AIHA • Cold ... perfringens - Complement-Mediated ... immune-complex hemolytic anemia ... MAHA (TTP, DIC, HUS
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
• Symptoms of anemia ... Positive Coombs testing ... Mycoplasma, EBV, HIV ... temperatures by fixing complement ... Symptoms: High fevers
Hemolytic Anemia - Differential Diagnosis Algorithm
 • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... Agglutination - Cold ... DIC, TTP, HELLP, HUS ... bartonella (oroya fever ... workup #hematology #testing
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
tract, and often causes ... often involved • Hypocomplementemic ... Urticaria and hypocomplementemia ... Vasculitis: • Fevers ... against MPO • Complement
Chest Pain Diagnosis and Management Algorithm
STEMI:
 - Hx: Pressure like CP, Radiation to arm/jaw, CAD risk
and Management Algorithm ... onset, severe, tearing ... friction rub, Fever ... caustic ingestion, HIV ... , Dyspnea, H/O COPD