13 results
diagnosis rheumatology management vasculitis differential disease glomerular nephrology nephrotic workup agglutinin anemia blood cold cryoglobulinemia cryoglobulins disorders erythematosus gammopathy glomerulonephritis
Causes of Hypocomplementemia - CHAMPS Mnemonic C - Cryoglobulinemia (85%), C3 glomerulopathy, cirrhosis H - Heavy Chain deposition
Causes of Hypocomplementemia ... - CHAMPS Mnemonic ... @AnnKumfer #Hypocomplementemia ... #Low #Complement ... #differential #hematology
Pathophysiology of Hypocomplementemic Urticarial Vasculitis C1q/anti-C1q antibiody -> Immune Complex Formation - Complement Pathway Activation (C3a and C5a)
Pathophysiology of Hypocomplementemic ... Complex Formation - Complement ... TerrierBen #Hypocomplementemic ... Pathophysiology #Rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
often involved • Hypocomplementemic ... Urticaria and hypocomplementemia ... against MPO • Complement ... differential #diagnosis #rheumatology ... #classification
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
Types: • Type ... • Type III Often ... • Low serum C4 complement ... #classification ... #rheumatology #
Recommended initial testing for patients being evaluated for glomerular disease 24-hour urine collection - Quantify proteinuria.
Recommended initial testing ... SPEP+free light chains ... or alternative complement ... cryoglobulinemias (types ... #glomerular #testing
Recommended initial testing for patients being evaluated for glomerular disease 1) 24-hour urine collection - Quantify proteinuria.
Recommended initial testing ... or alternative complement ... SPEP+free light chains ... cryoglobulinemias (types ... diagnosis #initial #testing
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Agglutinin Disease 3 Types ... Positive Coombs testing ... post infectious setting ... temperatures by fixing complement ... hemolytic #anemia #hematology
Post-Transplantation Lymphoproliferative Disorders (PTLD) Definition: Lymphoid and/or plasmacytic proliferations that occur as a result of immunosuppression in
immunosuppression in the setting ... by transplant type ... organ transplant: Type ... symptoms, unexplained hematologic ... Diagnosis and classification
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
Cytopenia: 2% • Hypocomplementemia ... • Can cause TYPE ... IV RTA, TYPE I ... nephritis • Distal (Type ... Nephrogenic DI Hematologic
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
anti-Smith Ab, low complements ... Skin Disease Classification ... Malignancy (e.g. hematologic ... Kikuchi disease • Type-I ... RNP antibodies, Complement
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