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diagnosis rheumatology differential hematology lupus erythematosus management vasculitis champs chronic classification cll comparison druginduced leukemia lymphocytic mnemonic oncology polycythemia summary
Causes of Hypocomplementemia - CHAMPS Mnemonic C - Cryoglobulinemia (85%), C3 glomerulopathy, cirrhosis H - Heavy Chain deposition
Causes of Hypocomplementemia ... glomerulonephritis (>90%) S - Systemic ... @AnnKumfer #Hypocomplementemia ... #Low #Complement
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
Systemic Lupus Erythematosus ... • Immunologic Workup ... 60-80% - Low ... complement - 50 ... #lupus #Systemic
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
often involved • Hypocomplementemic ... Urticaria and hypocomplementemia ... neuropathy - GI ... (Low levels mixed ... vasculitis, and SLE
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
• Immunologic Workup ... in >90% - Low ... complement - Rare ... months to years) Systemic ... complement - 50
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
Diagnosis: • Systemic ... diseases, such as SLE ... mononeuritis multiplex • GI ... Elevated AST ALT • Hypocomplementemia ... Vasculitis) • Hypocomplementemic
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... anti-Smith Ab, low ... complements and ... pericardial/abd GI ... , lymphopenia, low
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
rendering the immune system ... non-Hodgkin lymphoma SLL ... ’s CLL Scoring system ... acute leukemia • GI ... Leukemia #diagnosis #workup
Polycythemia - Differential Diagnosis Algorithm Polycythemia itself isn’t a diagnosis. Like many things, it is a condition
Differential Diagnosis Algorithm ... frequently affected systems ... some time, let’s see ... levels: realllly low ... #workup #hematology
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