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diagnosis rheumatology differential management champs gammopathy hematology igg4 low mgrs mnemonic monoclonal phenotypes related renal significance sjogrens syndrome vasculitides vasculitis
Causes of Hypocomplementemia - CHAMPS Mnemonic C - Cryoglobulinemia (85%), C3 glomerulopathy, cirrhosis H - Heavy Chain deposition
Causes of Hypocomplementemia ... Chain deposition disease ... @AnnKumfer #Hypocomplementemia ... #Low #Complement
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
often involved • Hypocomplementemic ... Urticaria and hypocomplementemia ... (Granulomatous disease ... against MPO • Complement ... #rheumatology #classification
IgG4-Related Disease Clinical history: Man, 60 years, multiorgan involvement, unique or multiple inflammatory pseudotumor 4 phenotypes: •
IgG4-Related Disease ... with response to treatment ... rheumatoid factor), ± hypocomplementemia ... IgG4+ cells" Treatment ... IgG4 #Related #Disease
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
multisystemic disease ... associated with other diseases ... Cytopenia: 2% • Hypocomplementemia ... demyelinating disease ... Adenocarcinoma Treatment
Monoclonal Gammopathy of Renal Significance (MGRS) MGRS • MGRS refers to kidney disease caused by nephrotoxic monoclonal immunoglobulins
refers to kidney disease ... end-stage kidney disease ... guide subtype classification ... tubulopathy) - Complement ... microangiopathy Treatment
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