12 results
Causes of Severe Acute Liver Injury
 - Ichemic hepatitis
 - Acute biliary obstruction
 - Drug-Induced liver
Injury - Ichemic hepatitis ... injury - Viral Hepatitis ... - Autoimmune ... hepatitis - Wilson ... #Hepatology #Diagnosis
Summary of Coagulation Deficiencies
Inherited:
 • Hemophilia A - Deficiency of Factor VIII
 • Hemophilia B -
Summary of Coagulation ... ) • Advanced Liver ... , Viral hepatitis ... Septic shock, Obstetric ... comparison #diagnosis #hematology
Common Etiologies of Cirrhosis

Inflammation

 - Hepatitis B (15 percent)

 - Hepatitis C (47 percent)

 - Schistosomiasis
Inflammation - Hepatitis ... 15 percent) - Hepatitis ... α1-antitrypsin deficiency ... Nonalcoholic fatty liver ... #Hepatology #Cirrhosis
Causes of Bleeding / Bruising - Differential Diagnosis Algorithm
Thrombocytopenia - Quantitative Defect
 • Decreased Production
 •
Bleeding / Bruising - Differential ... - Acquired • Anticoagulation ... Iatrogenic) • Liver ... Bleeding #Bruising #Differential ... Algorithm #Causes #Hematology
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines

ACLF = possibly reversible condition in those with CLD (± cirrhosis)
disease, liver ... Kidney Failure Coagulation ... Alcohol-Associated Hepatitis ... ) Viral Hepatitis ... Failure #Cirrhosis #Hepatology
Elevated Liver Enzymes - Differential Diagnosis Algorithm
Severe ALT > 15x ULN
 • Viral
 • Drugs/Toxins
 •
Elevated Liver Enzymes ... • Ischemia • Autoimmune ... • Drugs • AIH ... • Alcoholic hepatitis ... Others #LFTs #Hepatology
Clinical Diagnosis of Autoimmune Hepatitis
 - Onset of jaundice within prior 8 weeks
 - Ongoing consumption
Hepatitis - Onset ... Possible ischemic hepatitis ... 1 antitrypsin deficiency ... #Hepatitis #Diagnosis ... #Hepatology #AIH
Autoimmune Hepatitis

Clinical Presentation
 - Highly variable clinical presentation, from subclinical disease to acute liver failure.
 -
Autoimmune Hepatitis ... from subclinical disease ... Other Etiology of Hepatitis ... #Hepatitis #AIH ... #Hepatology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes
Intravascular Hemolysis:
 • Mechanical Trauma (Microangiopathic hemolytic anemia):
intravascular coagulation ... (AIHA) "Warm" ( ... G6PD deficiency) ... Extravascular #Causes #differential ... #diagnosis #hematology
Common Variable Immunodeficiency (CVID)

What?
CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
Liver diseases ... and hepatitis ... : Pneumonia • Autoimmune ... hypogammaglobulinemia #immunology #hematology ... #diagnosis #management