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diagnosis immunocompromised hematology humoral immunity infections rheumatology agglutinin algorithm anemia asplenia causes classification cold diagram disease erythematosus hemolytic immunecompromised immunodeficiency
Infectious Risks in Asplenia and Deficiencies in Humoral Immunity and Complement - Venn Diagram Humoral Immunity: •
and Complement ... Diagram Humoral Immunity ... T and B cells Complement ... PrathitKulkarni #complement ... immunocompromised #infections #differential
Infections in Immunocompromised Patients - Differential Diagnosis Summary Innate Immunity: • Neutropenia • Phagocytic Deficiencies • Complement
Immunocompromised Patients - Differential ... Summary Innate Immunity ... Deficiencies • Complement ... Cell-Mediated Immunity ... Immunocompromised #Infections #differential
Humoral Immunity - Pathogenesis and Clinical Findings Antigens (Ag) are produced from pathogens (bacteria, viruses, fungi, parasites)
Humoral Immunity ... activation • Complement ... contribute to immunity ... proliferate and differentiate ... exposure #Humoral #Immunity
Pulmonary Renal Syndromes and Mimics - Differential Diagnosis Framework Diffuse alveolar hemorrhage + rapidly progressive glomerulonephritis 90%: -
Syndromes and Mimics - Differential ... anti-GBM) 10%: - Low Complement ... Vasculitis - Normal Complement ... other hemorrhagic fevers ... Syndromes #Mimics #Differential
Causes of Fever in the Immunocompromised Host - Differential Diagnosis Algorithm Structural Defect - Asplenia/HypospIenism • Bacteremia/Septic
Causes of Fever ... Immunocompromised Host - Differential ... Cell Mediated Immunity ... Periodontal Disease Complement ... Infection #Fever
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
Vasculitides - Differential ... Coronary arteries - Fever ... ear disease Differential ... Vasculitis: • Fevers ... against MPO • Complement
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
younger pts) Differential ... temperatures by fixing complement ... Symptoms: High fevers
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
weight loss, and fever ... anti-Smith Ab, low complements ... permanent alopecia Differential ... to: Arthritis, Fever ... RNP antibodies, Complement
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