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rheumatology hemophagocytic lymphohistiocytosis treatment aosd blood product reactions summary activation adult adultonset algorithm arthritis classification gastroenterology hemeonc hemochromatosis hepatology hodgkins
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
, ↓ Fibrinogen level ... • Autoimmune diseases ... +, Adult-onset Still ... disease, Infection ... #management #treatment
Hemophagocytic Lymphohistiocytosis (HLH) Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
frequently affects infants ... age, however the disease ... If no response HLH ... #management #treatment ... #hematology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
• Adult-onset Still ... hypersensitivity syndromes • HLH ... ALT ↑ bilirubin level ... Activation #Syndrome #Diagnosis ... #Management #Hematology
Adult-Onset Still's Disease (AOSD) Rare inflammatory disorder of unknown etiology, difficult to diagnose because of heterogenous presentation.
Adult-Onset Still's ... Disease (AOSD) ... Life-threatening ... #rheumatology #diagnosis ... #management #treatment
Algorithm regarding the diagnosis and treatment of Hereditary Hemochromatosis HH. Step 1: In the patient with
regarding the diagnosis ... disease. ... and hematologic ... hemochromatosis #algorithm #diagnosis ... #management #hepatology
Adult Onset Still's Disease Systemic inflammation with urticarial rash. Rash: • Nonpruritic, evanescent (correlates with time of
Adult Onset Still's ... • If uncontrolled ... #Adult #onset #Stills ... #diagnosis #rheumatology ... #management
Hemophagocytic Lymphohistiocytosis (HLH) High mortality without prompt recognition and management. HLH is a critical diagnostic consideration in
recognition and management ... Onset: Usually in infancy ... ▪ Autoimmune diseases ... Approach • Initial management ... #Management #Hematology
Septic Arthritis - Diagnosis and Management Summary Clinical Exam: hot, swollen, pain with passive AND active ROM
and Management ... active ROM +/- fever ... , chills, malaise ... necrosis, Lyme disease ... 90% sensitive in pediatrics
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
• Dyspnea • Fever ... marrow biopsy - if ... number of sites of disease ... classification #hematology ... #oncology #management
Blood Transfusion Reactions Immune Mediated: • Febrile Non-Hemolytic Transfusion Reaction (FNHTR): Most common immune reaction to transfusion.
donors (due to anti-HLA ... Graft Versus Host Disease ... Borrellia (Lyme disease ... #Transfusion #diagnosis ... #management #hematology
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