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hematology disease summary syndrome treatment activation adult adultonset apml arthritis cardiology classification differentiation endocarditis fungal hemophagocytic hlh hodgkins infections infectiousdiseases
Adult-Onset Still's Disease (AOSD) Rare inflammatory disorder of unknown etiology, difficult to diagnose because of heterogenous presentation.
Adult-Onset Still's ... Life-threatening ... #AdultOnset #Stills ... #rheumatology #diagnosis ... #management #treatment
Adult Onset Still's Disease Systemic inflammation with urticarial rash. Rash: • Nonpruritic, evanescent (correlates with time of
Adult Onset Still's ... • If uncontrolled ... #disease #AOSD ... #diagnosis #rheumatology ... #management
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
• Adult-onset Still ... erythematosus [SLE], AOSD ... ALT ↑ bilirubin level ... Activation #Syndrome #Diagnosis ... #Management #Hematology
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
• Clinical: fever ... , ↓ Fibrinogen level ... +, Adult-onset Still ... #management #treatment ... #summary #rheumatology
Septic Arthritis - Diagnosis and Management Summary Clinical Exam: hot, swollen, pain with passive AND active ROM
and Management ... active ROM +/- fever ... , chills, malaise ... 90% sensitive in pediatrics ... anal Cxs) • *** If
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Prophylaxis: • Attempt if ... high risk if WBC ... Subacute-Acute: • Common: fever ... #management #hematology ... #oncology
Endocarditis Summary Who? Infectious: • Pre-existing valvular disease • Prosthetic valve • Congenital heart disease • IV substance use • IV catheter • Recent
Generalized: • Chills ... night sweats, fever ... Differential Diagnosis ... Paradoxical emboli via ASD ... #management #cardiology
Mycoses HISTOPLASMOSIS • Inhalation of conidia → Yeast → travel to lymph nodes → spread in body • Bird
, cough, chills, ... pulmonary symptoms • Rheumatologic ... , chills, muscle ... device removal (if ... #Management #Infections
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
• Dyspnea • Fever ... lymph node biopsy (diagnostic ... marrow biopsy - if ... Hodgkins #lymphoma #diagnosis ... #oncology #management
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