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disease stills treatment admissions admitting adult adultonset algorithm apml criticalcare differentiation epilepticus hematology hemophagocytic hlh lymphohistiocytosis neurology oncology onset pearls
Adult-Onset Still's Disease (AOSD) Rare inflammatory disorder of unknown etiology, difficult to diagnose because of heterogenous presentation.
, difficult to diagnose ... malignant) to diagnose ... Life-threatening ... #rheumatology # ... diagnosis #management
Admitting in the ICU - Checklist VITALS: If bad, stop and go see the patient immediately; you
- Checklist VITALS ... esp in work-up/management ... bedside echo is never ... #Pearls #Checklist ... #diagnosis #workup
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
• Clinical: fever ... , ↓ Fibrinogen level ... of emergency, ICU ... #management #treatment ... #summary #rheumatology
Adult Onset Still's Disease Systemic inflammation with urticarial rash. Rash: • Nonpruritic, evanescent (correlates with time of
• Leukocytosis Diagnosis ... • If uncontrolled ... Stills #disease #AOSD ... #diagnosis #rheumatology ... #management
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Prophylaxis: • Attempt if ... high risk if WBC ... Subacute-Acute: • Common: fever ... organ dysfuxtion, ICU ... #management #hematology
Management of Convulsive Status Epilepticus in children Stabilization Phase (Seizure 0-5 minutes): • Check and maintain ABC
Management of Convulsive ... blood glucose level ... : • Admit to PICU ... #neurology #pediatrics ... #peds #algorithm
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