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hematology hemophagocytic lymphohistiocytosis treatment blood product reactions stills activation adult adultonset classification hemeonc hodgkins lymphoma macrophage mas oncology onset summary
Hemophagocytic Lymphohistiocytosis (HLH) Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
frequently affects infants ... age, however the disease ... acute or subacute febrile ... If no response HLH ... #management #treatment
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
erythematosus [SLE], AOSD ... ALT ↑ bilirubin level ... Activation #Syndrome #Diagnosis ... #Management #Hematology ... #Rheumatology
Adult-Onset Still's Disease (AOSD) Rare inflammatory disorder of unknown etiology, difficult to diagnose because of heterogenous presentation.
Adult-Onset Still's Disease ... Life-threatening ... AdultOnset #Stills #Disease ... #AOSD #rheumatology ... #diagnosis #management
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
, ↓ Fibrinogen level ... • Autoimmune diseases ... Adult-onset Still disease ... #management #treatment ... #summary #rheumatology
Adult Onset Still's Disease Systemic inflammation with urticarial rash. Rash: • Nonpruritic, evanescent (correlates with time of
extremities during febrile ... • If uncontrolled ... #AOSD #diagnosis ... #rheumatology # ... management
Hemophagocytic Lymphohistiocytosis (HLH) High mortality without prompt recognition and management. HLH is a critical diagnostic consideration in
recognition and management ... in febrile illness ... Onset: Usually in infancy ... ▪ Autoimmune diseases ... #Management #Hematology
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
• Dyspnea • Fever ... lymph node biopsy (diagnostic ... marrow biopsy - if ... number of sites of disease ... #oncology #management
Blood Transfusion Reactions Immune Mediated: • Febrile Non-Hemolytic Transfusion Reaction (FNHTR): Most common immune reaction to transfusion.
Mediated: • Febrile ... donors (due to anti-HLA ... Borrellia (Lyme disease ... #Transfusion #diagnosis ... #management #hematology
Blood Product Transfusions One Pager Summary Type and screen - determines blood type and detects in recipient
Mediated: - Febrile ... donors (due to anti-HLA ... Borrellia (Lyme disease ... #Transfusions #diagnosis ... #management #hematology
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