15 results
Adult-Onset Still's Disease (AOSD)
Rare inflammatory disorder of unknown etiology, difficult to diagnose because of heterogenous presentation.
Life-threatening ... synovitis (40%) Treatment ... #rheumatology # ... diagnosis #management ... #treatment
“Step by Step” – the new kid on the block – aims to risk stratify this
investigations and treatments ... “low risk” an infant ... CRP < 20 mg/L #Diagnosis ... #Management #Pediatrics ... #Peds #Febrile
The Febrile Infant Step-by-Step Algorithm
This is an algorithm developed by European emergency physicians to identify low-risk
The Febrile Infant ... empiric antibiotic treatment ... #EBM #Management ... #Pediatrics #Peds ... #Febrile #Infant
Hemophagocytic Lymphohistiocytosis (HLH)
Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
frequently affects infants ... acute or subacute febrile ... If no response HLH ... #management #treatment ... #hematology
Adult Onset Still's Disease
Systemic inflammation with urticarial rash.
Rash: 
 • Nonpruritic, evanescent (correlates with time of
extremities during febrile ... • If uncontrolled ... Stills #disease #AOSD ... #diagnosis #rheumatology ... #management
Hemophagocytic Lymphohistiocytosis (HLH)
Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
, ↓ Fibrinogen level ... Drugs, Unknown cause ... Treatment: • ... #management #treatment ... #summary #rheumatology
Kawasaki Disease (KD) - Diagnosis and Management Summary

Kawasaki Disease (KD) is the most common vasculitis of
and Management ... , Cough • +/-Nausea ... KD #vasculitis #rheumatology ... #pediatrics #diagnossi ... #management #treatment
Leukostasis vs Tumor Lysis Syndrome
Leukostasis:
 • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
high WBC count cause ... - 80% have fever ... : - If febrile ... Syndrome #TLS #diagnosis ... #management #hematology
Peri-operative Hyperthermia - Guidelines for Crises in Anaesthesia
If prolonged or ≥ 39 C this is a
in Anaesthesia If ... Treatment depends ... devices, especially infants ... Anesthesia #Checklist #Diagnosis ... #Management #Workup
Differentiation Syndrome in APML
Epidemiology:
 • Incidence: common in APL (2-48% depending on the study)
 • Triggers:
Triggers: ATRA treatment ... Subacute-Acute: • Common: fever ... Rare: DAH, acute febrile ... Renal Failure Treatment ... #management #hematology