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hematology algorithm disease hemophagocytic lymphohistiocytosis peds syndrome antibiotics blood fever lp oncology product reactions risk stepbystep stratification activation adult aosd
Hemophagocytic Lymphohistiocytosis (HLH) Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
frequently affects infants ... acute or subacute febrile ... If no response HLH ... #management #treatment ... #hematology
Kawasaki Disease (KD) - Diagnosis and Management Summary Kawasaki Disease (KD) is the most common vasculitis of
Kawasaki Disease ... (KD) - Diagnosis ... KD #vasculitis #rheumatology ... #pediatrics #diagnossi ... #management #treatment
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
• Clinical: fever ... , ↓ Fibrinogen level ... Unknown cause Treatment ... #management #treatment ... #summary #rheumatology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
erythematosus • Kawasaki ... ALT ↑ bilirubin level ... Treatment: • Corticosteroids ... Activation #Syndrome #Diagnosis ... #Management #Hematology
“Step by Step” – the new kid on the block – aims to risk stratify this
investigations and treatments ... “low risk” an infant ... CRP < 20 mg/L #Diagnosis ... #Management #Pediatrics ... #Peds #Febrile
The Febrile Infant Step-by-Step Algorithm This is an algorithm developed by European emergency physicians to identify low-risk
The Febrile Infant ... empiric antibiotic treatment ... #EBM #Management ... #Pediatrics #Peds ... #Febrile #Infant
Hemophagocytic Lymphohistiocytosis (HLH) High mortality without prompt recognition and management. HLH is a critical diagnostic consideration in
recognition and management ... in febrile illness ... Onset: Usually in infancy ... Treatment Approach ... #Management #Hematology
Evaluation of suspected incomplete Kawasaki Disease 1. AHA consensus recommendations 2. Infants ≤6 months old on day ≥7
suspected incomplete Kawasaki ... Infants ≤6 months ... , treatment should ... #Diagnosis #Peds ... #Pediatrics #Kawasaki
Adult Onset Still's Disease Systemic inflammation with urticarial rash. Rash: • Nonpruritic, evanescent (correlates with time of
extremities during febrile ... Treatment - Mild ... • If uncontrolled ... #rheumatology # ... management
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
- 80% have fever ... organ damage • Treatment ... : - If febrile ... Syndrome #TLS #diagnosis ... #management #hematology
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