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diagnosis treatment hematology hemophagocytic hlh latenttb lymphohistiocytosis tb tuberculosis agitation amiodarone criticalcare delirium differential hemeonc icu induced inflammatory iris lung
Statin Induced Muscle Toxicity - Summary Clinical Presentation: • Elevations of serum creatine kinase with proximal myalgia
Induced Muscle Toxicity ... , immune-mediated ... increased spontaneous activity ... Statin #muscle #toxicity ... myopathy #diagnosis #management
Tuberculosis Overview 10 million new M. tuberculosis infections/year Facultative intracellular rod-shaped bacteria Multidrug-resistant tuberculosis (MDR-TB) accounts for 4.6% of
IFN-γ-activated ... Progression: (+) Immune ... rest LTBI (-) Immune ... TB: • Fever • ... TB #Diagnosis #Management
Sarcoidosis - Diagnosis and Management Summary Epidemiology 1) High incidence in Scandinavian countries (11-24 cases per 100,000 individuals
Diagnosis and Management ... increased B-cell activity ... → local immune ... Pulmonary: dyspnea ... acute sarcoidosis Pulmonary
Tuberculosis Overview 10 million new M. tuberculosis infections/year Facultative intracellular rod-shaped bacteria Multidrug-resistant tuberculosis (MDR-TB) accounts for 4.6% of
IFN-γ-activated ... Progression: (+) Immune ... rest LTBI (-) Immune ... TB: • Fever • ... TB #Diagnosis #Management
Hemophagocytic Lymphohistiocytosis (HLH) Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
Overwhelming clinical syndrome ... underlying genetic immune ... absent NK cell activity ... If no response HLH ... Lymphohistiocytosis #diagnosis #management
Immune Reconstitution Inflammatory Syndrome - Overview of IRIS What Is IRIS? • A state of hyperinflammatory response that
Inflammatory Syndrome ... decrease in HIV-1 RNA level ... Drug reaction/ART toxicity ... • Persistently active ... Differential #Diagnosis #Management
Pain, Agitation, and Delirium (PAD) in the ICU Addressing the ICU Triad (PAD) can be accomplished through
tool to assess level ... Propofol infusion syndrome ... glycol (solvent) toxicity ... No pharmacologic ... CriticalCare #diagnosis #management
Amiodarone Induced Lung Toxicity Summary Who? • 5% of patients • Dose ≥ 400 mg per day How? Possible
Amiodarone half life ... respiratory distress syndrome ... Fever 4. ... #Pulmonary #diagnosis ... #management #Toxicology
Hemophagocytic Lymphohistiocytosis (HLH) High mortality without prompt recognition and management. HLH is a critical diagnostic consideration in
recognition and management ... hyperinflammatory syndrome ... activation of the immune ... to uncontrolled immune ... absent NK-cell activity
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
Disease: • 10%-15% Pulmonary ... , INC risk PE, Pulmonary ... lubricants • Pharmacologic ... muscarinic agonists • Active ... Rheumatology #Diagnosis #Management
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