1422 results
Systemic Lupus Erythematosus (SLE): Pathogenesis

 • Genetic factors (Mutations in HLA- DR2/HLA-DR3 genes, complement genes, cytokine
Erythematosus (SLE ... system defects (i.e ... Interferon-a, IL ... Erythematosus #SLE ... #Pathophysiology
Classification of COVID-19 Disease States and Potential Therapeutic Targets

Viral Response Phase -> Host Inflammatory Response Phase
Stage
Phase) Stage Ill ... immunoglobulin, IL ... -6 inhibitors, IL ... Classification #Diagnosis #Pathophysiology
Mechanism of Action of Bile Acid Sequestrants
Bile Acid Sequestrants → ↓ Hepatic Bile Acid Pool →
Mechanism of Action of Bile ... Sequestrants Bile ... Sequestrants → ↓ Hepatic Bile ... Pool → ↑ Hepatic Bile ... sequestration #pathophysiology
Heme Synthesis Pathway
Enzymes
1. ALA Synthase
2. ALA Dehydratase
3. Porphobilinogen deaminase
4. UP Ill Synthase
5. UP Ill Decarboxylase
6. Coproporphyrinogen
UP Ill Synthase ... UP Ill Decarboxylase ... Synthesis #Pathway #pathophysiology
Maculopapular - Diagnostic Algorithm
Pathophysiology:
- Catch-all term with a wide range of potential pathophysiologic mechanisms and causative
Diagnostic Algorithm Pathophysiology ... range of potential pathophysiologic ... - Pathophysiology ... consultations): - Ill-appearing
Asthma: immunopathogenesis. 
Allergens attach to, and are taken up by, dendritic cells that he the respiratory
IL-4 activates B ... and release IgE ... allergens bridge two IgE ... are activated by IL ... immunopathogenesis #Pathophysiology
Central Retinal Artery Occlusion: Pathogenesis and clinical findings
 • Inflammatory Disease: (i.e. GCA, SLE, GPA) ->
Inflammatory Disease: (i.e ... GCA, SLE, GPA) - ... Cardiogenic Embolism: (i.e ... Hematologic Disease: (i.e ... Occlusion #CRAO #pathophysiology
Hypothermia in Sepsis - Pathophysiology
 • 20% of septic pts → HYPOTHERMIA
 • Increased mortality 62%
Hypothermia in Sepsis - Pathophysiology ... cytokines ↓TNF-α, ↓IL ... -6, ↓IL-1 3. ... cytokine response ↑IL ... Hypothermia #sepsis #pathophysiology
Interstitial Lung Diseases (ILD)
Exposure-Related ILD (a.k.a. extrinsic allergic alveolitis): 
 • Hypersensitivity pneumonitis, Farmer's lung, Bird
Lung Diseases (ILD ... Exposure-Related ILD ... Pneumoconioses (i.e ... Methotrexate ILD ... lung disease (RB-ILD
Obesity in the Critically Ill is quite the problem. It worsens the prognosis in our ICU
the Critically Ill ... illness #critical #pathophysiology