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diagnosis differential dermatology secondary classification generalized pruritus approach common cvid fatigue hypertension hypogammaglobulinemia immunodeficiency immunology management naildisorders primary pulmonary pulmonaryhypertension
Causes of Pulmonary Hypertension - Differential Diagnosis Algorithm Pulmonary Arterial Hypertension • Idiopathic • Associated with:
Causes of Pulmonary ... Dysfunction: • Systolic ... Miscellaneous: • Hematologic ... Disorders Chronic ... PulmonaryHypertension #PHTN
Causes of Thrombocytosis - Differential Diagnosis Algorithm Spurious: • Artifact (redo CBC) Autonomous: • Essential thrombocytosis • Polycythemia
Causes of Thrombocytosis ... : • Acute or Chronic ... • Rheumatic disorders ... Iron deficiency anemia ... #Causes #Hematology
Overall Approach to Anemia - Differential Diagnosis Algorithm Blood Loss • Acute Bleed - Normocytic / Normochromic
Differential Diagnosis Algorithm ... RBCs on Smear • Chronic ... • Anemia of Chronic ... • RBC Membrane Disorder ... #Causes #Hematology
Clinical Classification of Pulmonary Hypertension 1. Pulmonary arterial hypertension from pulmonary vasculopathy Idiopathic pulmonary arterial hypertension Heritable gene mutations
hemolytic anemia ... multifactorial mechanisms Hematologic ... Systemic disorders ... #Hypertension #PHTN ... #Differential #Causes
Nail Disorders secondary to Systemic Diseases Nail Fold Abnormality • SLE • Scleroderma • Dermatomyositis Koilonychia - Spoon-shaped
Nail Disorders secondary ... Iron deficiency anemia ... discoloration) • Chronic ... Differential #Diagnosis #Algorithm ... #causes
Causes of Fatigue - Differential Diagnosis Algorithm Endocrine • Hypo/Hyperthyroidism • Diabetes • Pituitary Insufficiency • Adrenal
Causes of Fatigue ... Neoplastic / Hematologic ... • Anemia • ... • Somatization Disorder ... #causes
Pruritus - Generalized Differential Diagnosis Algorithm - Systemic and Primary Causes == Primary Skin Lesions == Macules /
Differential Diagnosis Algorithm ... Primary Causes ... Creatinine & BUN: • Chronic ... renal failure/uremia ... #causes
Common Variable Immunodeficiency (CVID) What? CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
Immunodeficiency disorder ... autoimmune hemolytic anemia ... ) • Systemic granulomatous ... DDX - Other causes ... hypogammaglobulinemia #immunology #hematology
Pruritus - No Primary Skin Lesion - Differential Diagnosis Algorithm Blood Glucose: • Diabetes Mellitus Liver Function Tests/Enzymes:
Creatinine & BUN: • Chronic ... renal failure/uremia ... Pruritus #secondary #systemic ... #generalized #dermatology ... #causes
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