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diagnosis hematology oncology rheumatology chronic hemeonc hemophagocytic hlh leukemia lymphocytic lymphohistiocytosis treatment workup agglutinin amyloid amyloidosis anemia barre bleeding cell
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
: • Most common ... Orange or Hep C Clinical ... lymphoproliferative disorders ... • Richter’s Syndrome ... leukemia • Sezary syndrome
Common Variable Immunodeficiency (CVID) What? CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
Immunodeficiency disorder ... to impaired B-cell ... to 8 years Clinical ... severe community-acquired ... : • Nephrotic syndrome
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Cold Agglutinin Syndrome ... Viral Infection Clinical ... symptoms - most common ... malignancies -> CLL ... hemolytic #anemia #hematology
Helpful Clinical Features in Evaluating Bleeding Disorders Age of onset • Neonate - in 20% of haemophilias,
Helpful Clinical ... relatives (if all ... bleeding tendency is acquired ... Marfan syndrome, ... osteogenesis imperfecta
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
Macrophage Activation ... the secondary or acquired ... Clinical Presentation ... Fever is the main clinical ... #Management #Hematology
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
Overview: • Most common ... leukemia in adults • Disorder ... immunophenotype Clinical ... routine CBC (rnost common ... hemeonc #diagnosis #management
Hemophagocytic Lymphohistiocytosis (HLH) Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
: Overwhelming clinical ... syndrome associated ... excessive macrophage activation ... symptoms can mimic common ... Lymphohistiocytosis #diagnosis #management
Hemophagocytic Lymphohistiocytosis (HLH) High mortality without prompt recognition and management. HLH is a critical diagnostic consideration in
• Secondary (Acquired ... ) HLH: - Common ... Clinical Presentation ... • Common Signs ... malignancy, autoimmune disorder
Hepatopulmonary Syndrome - Diagnosis and Management Summary A defect in arterial oxygenation due to a gas exchange
Hepatopulmonary Syndrome ... a gas exchange disorder ... shunt (Type 2) Clinical ... • Dyspnea - Common ... #treatment #hepatology
Guillain-Barré Syndrome (GBS) Acute autoimmune demyelinating polyradiculoneuropathy that presents with rapidly progressive flaccid weakness Epidemiology: • Incidence: 1
Guillain-Barré Syndrome ... Common organisms ... : • Most common ... transplantation CLINICAL ... #diagnosis #management
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