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diagnosis hematology oncology chronic eosinophils hemeonc hemophagocytic hes hlh hypereosinophilia leukemia lymphocytic lymphohistiocytosis treatment workup agglutinin algorithm anemia barre bleeding
Hypereosinophilia and Hypereosinophilic Syndrome • Secondary Hypereosinophilic Syndrome • Clinically Relevant HES Variants • When to
• Clinically ... underlying hematologic disorders ... #HES #Hematology ... #eosinophilia # ... #management #algorithm
Hypereosinophilia Syndrome (HES) - Diagnosis and Management Definition: An absolute eosinophil count (AEC) greater than 1500 and
Hypereosinophilia Syndrome ... Diagnosis and Management ... than 1500 and clinical ... - Immunologic disorders ... #diagnosis #hematology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
: • Most common ... Orange or Hep C Clinical ... lymphoproliferative disorders ... • Richter’s Syndrome ... leukemia • Sezary syndrome
Common Variable Immunodeficiency (CVID) What? CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
Immunodeficiency disorder ... to impaired B-cell ... to 8 years Clinical ... severe community-acquired ... : • Nephrotic syndrome
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Cold Agglutinin Syndrome ... Viral Infection Clinical ... symptoms - most common ... malignancies -> CLL ... hemolytic #anemia #hematology
Helpful Clinical Features in Evaluating Bleeding Disorders Age of onset • Neonate - in 20% of haemophilias,
Helpful Clinical ... relatives (if all ... bleeding tendency is acquired ... Marfan syndrome, ... osteogenesis imperfecta
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
Lymphocytic Leukemia (CLL ... Overview: • Most common ... leukemia in adults • Disorder ... immunophenotype Clinical ... hemeonc #diagnosis #management
Hepatopulmonary Syndrome - Diagnosis and Management Summary A defect in arterial oxygenation due to a gas exchange
Hepatopulmonary Syndrome ... a gas exchange disorder ... shunt (Type 2) Clinical ... • Dyspnea - Common ... #treatment #hepatology
Guillain-Barré Syndrome (GBS) Acute autoimmune demyelinating polyradiculoneuropathy that presents with rapidly progressive flaccid weakness Epidemiology: • Incidence: 1
Guillain-Barré Syndrome ... Common organisms ... : • Most common ... transplantation CLINICAL ... #diagnosis #management
Hemophagocytic Lymphohistiocytosis (HLH) Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
: Overwhelming clinical ... syndrome associated ... symptoms can mimic common ... Low or absent NK cell ... Lymphohistiocytosis #diagnosis #management
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