18 results
Hypereosinophilia and Hypereosinophilic Syndrome

 • Secondary Hypereosinophilic Syndrome
 • Clinically Relevant HES Variants
 • When to
Clinically ... Relevant HES Variants ... underlying hematologic disorders ... #HES #Hematology ... eosinophils #diagnosis #management
Acquired von Willebrand Syndrome - Diagnosis and Management
 • Autoantibodies to vWF: Lymphoproliferative disorders (e.g. lymphoma,
Acquired von Willebrand ... Syndrome - Diagnosis ... and Management ... vonWillebrand #Syndrome ... #treatment #hematology
Inherited Non-hemolytic Disorders of Hyperbilirubinemia 

== Disorders of Conjugation ==
Gilbert Syndrome:
 • 5-10% of the population
population • Most common ... • Has a UGT1A1 ... as jaundice on clinical ... and malaise, are common ... Congenital #bilirubin #hepatology
Hypereosinophilia Syndrome (HES) - Diagnosis and Management
Definition: An absolute eosinophil count (AEC) greater than 1500 and
Hypereosinophilia Syndrome ... and Management ... than 1500 and clinical ... - Immunologic disorders ... #diagnosis #hematology
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework

== Quantitative or Qualitative defect in
and Bruising - Disorders ... of a platelet disorder ... von Willebrand syndrome ... defects in the common ... Differential #Diagnosis #Hematology
Common Variable Immunodeficiency (CVID)

What?
CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
Immunodeficiency disorder ... to 8 years Clinical ... severe community-acquired ... : • Nephrotic syndrome ... hypogammaglobulinemia #immunology #hematology
Helpful Clinical Features in Evaluating Bleeding Disorders
Age of onset
 • Neonate - in 20% of haemophilias,
Helpful Clinical ... bleeding tendency is acquired ... Marfan syndrome, ... osteogenesis imperfecta ... pediatrics #diagnosis #hematology
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
the secondary or acquired ... Clinical Presentation ... Fever is the main clinical ... #Diagnosis #Management ... #Hematology #Rheumatology
Hepatopulmonary Syndrome - Diagnosis and Management Summary
A defect in arterial oxygenation due to a gas exchange
Hepatopulmonary Syndrome ... a gas exchange disorder ... shunt (Type 2) Clinical ... • Dyspnea - Common ... #treatment #hepatology
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
lymphoproliferative disorder ... Cold Agglutinin Syndrome ... Viral Infection Clinical ... symptoms - most common ... hemolytic #anemia #hematology