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diagnosis hematology causes differential pt abnormal anticoagulant anticoagulation apixaban bleeding bruising cascade clot dabigatran dic disorders disseminated edoxaban hemorrhage hemostasis
Algorithm for Investigation of Abnormal Coagulation Tests - Prolonged PT - Prolonged aPTT and Prolonged PT - Prolonged aPTT Dr.
Algorithm for Investigation ... of Abnormal Coagulation ... aPTT and Prolonged ... DrEricStrong #Algorithm ... #Coagulation #Abnormal
Causes of Abnormal PT and/or aPTT Prolonged Prothrombin Time (PT) 1. Acquired deficiency of FVII
Congenital intrinsic ... coagulation factors ... drugs e.g. direct thrombin ... intravascular coagulation ... differential #hematology #coagulation
Causes of Prolonged PT (INR), Prolonged PTT • Prolonged PT (INR), Prolonged PTT • Prolonged PT
PTT • Prolonged ... PTT • Prolonged ... • Prolonged PTT ... Differential #Diagnosis #Algorithm ... Causes #Hematology #coagulation
Differential Diagnosis for a Prolonged PT and aPTT If the PT and the aPTT are both prolonged,
PT and aPTT If ... the PT and the aPTT ... affected in the intrinsic ... drugs (e.g. direct thrombin ... differential #hematology #coagulation
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
Thrombocytopenia • Prolonged ... PT/PTT • Low ... • Increased thrombin ... PT/INR: ↑ • PTT ... INR < 2.3 - APTT
The coagulation cascade is shown, separated into different phases with their endogenous and pharmacological inhibitors shown.
The coagulation ... along with FXIIa (intrinsic ... Thrombin, then primes ... #Coagulation #Cascade ... #clot #PT #PTT
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework == Quantitative or Qualitative defect in
inhibitor of a coagulation ... Abnormality in the intrinsic ... the PT remains prolonged ... pathway to the intrinsic ... warfarin, direct thrombin
Causes of Post-Partum Hemorrhage - Differential Diagnosis Algorithm Blood Loss: >500mL post vaginal delivery OR >1000 mL
Differential Diagnosis Algorithm ... fatigue (e.g. prolonged ... or percreta) Thrombin ... intravascular coagulation ... (DIC) • Anti-coagulation
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