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diagnosis geriatrics alzheimersdisease biliary causes cholangitis cirrhosis endocrinology evaluation falls feedbackloop genetics growthhormone heat heatstroke hepatology illness neurology pbc peds
Feedback Loop: Growth Hormone (GH) Growth Hormone: • Liver -> GHR activates JAK-STAT pathway -> Incr IGF1
Growth Hormone (GH ... Growth Hormone: • Liver ... activates lipolysis Signs ... /Symptoms: • GH ... endocrinology #pathophysiology
Prader-Willi Syndrome: Pathogenesis and clinical findings • Maternal uniparental disomy: inheriting 2 copies of maternal chromosome
Prader-Willi Syndrome Signs ... /Symptoms/Complications ... > Neonatal and infantile ... Syndrome #genetics #pathophysiology ... #peds #pediatrics
Alzheimer’s Disease: Pathogenesis and Clinical Findings Risk factor for Late Onset Alzheimer's (99% of cases): - Increasing
chromosome 21) Signs ... AlzheimersDisease #Dementia ... #pathophysiology ... #geriatrics #diagnosis ... #signs #symptoms
Primary Biliary Cirrhosis (PBC) - Summary PBC Epidemiology: • Female:Male 9:1 • Common European descent • Age:
65 years PBC Pathophysiology ... failure PBC Signs ... and Symptoms: ... or higher • Liver ... bile ducts Differential
Heat Illnesses and Heat Stroke - Differential Diagnosis Framework Heat Cramps: • Muscle pain or spasm -
Heat Stroke - Differential ... Collapse: • Pathophysiology ... → Syncope • Signs ... /Symptoms: - Lightheadedness ... heat #illness #differential
Evaluation of Recurrent Falls Core Concept: Maintaining an upright posture requires the integrated function of multiple systems. Disruption in
presyncope, exertional symptoms ... positive Romberg sign ... Examples: - Dementia ... Falls #Diagnosis #Differential ... #Evaluation #Geriatrics
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