10 results
Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI)

DILI Types:
 • Intrinsic - predictable, dose dependent
Diagnosis and Management ... Injury (DILI) ... dose dependent injury ... differential #Diagnosis #Management ... gastroenterology #hepatology
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm
DILI suspicion
Features toxic aetiology: Skin involvement, Kidney injury,
Injury (DILI) - ... involvement, Kidney injury ... disease, Hepatic ... presentation: Hepatic ... #Algorithm #hepatology
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework
Mild (<100-500): 
 • NAFLD
 • Cirrhosis
 •
Elevated Liver Function ... (>1000): • DILI ... injury) • Ischemic ... ) • Non-hepatic ... Differential #Diagnosis #hepatology
Acute Liver Injury - Differential Diagnosis Algorithm

Vascular Causes of Acute Liver Injury: 
 • Hepatic vein:
Acute Liver Injury ... Injury: • Hepatic ... Venoocclusive disease • Hepatic ... • Iatrogenic: DILI ... diagnosis #algorithm #hepatology
Appearance of Liver Lesions on Computed Tomography (CT) - Arterial Phase, Portal Venous Phase and Delayed
Appearance of Liver ... malformation, Infantile ... #Lesions #Hepatic ... diagnosis #comparison #table ... #appearance #hepatology
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines

ACLF = possibly reversible condition in those with CLD (± cirrhosis)
Acute-on-Chronic Liver ... Injury (DILI) ... Hepatitis Procedures Management ... Failure #Cirrhosis #Hepatology ... gastroenterology #management
Appearance of Liver Lesions on Various Imaging Modalities
 • Computed Tomography (CT) - Arterial Phase, Portal
Appearance of Liver ... malformation, Infantile ... #Lesions #Hepatic ... diagnosis #comparison #table ... #appearance #hepatology
Liver Chemistries - Interpretation of LFTs

R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP)
 • R >
injury < 26 weeks ... replaced by non-hepatic ... Unconjugated Bili ... > 90% of Total Bili ... #differential #Hepatology
Appearance of Liver Lesions on Contrast Enhanced Ultrasound - Early arterial, Grayscale phase, Late arterial phase,
Appearance of Liver ... malformation, Infantile ... #Lesions #Hepatic ... diagnosis #comparison #table ... #appearance #hepatology
Appearance of Liver Lesions on Magnetic Resonance Imaging (MRI) - T2, T1 precontrast, T1 portal venous,
Appearance of Liver ... malformation, Infantile ... #Lesions #Hepatic ... diagnosis #comparison #table ... #appearance #hepatology