18 results
Pathophysiology and Effects of Insulin Deficiency

#Insulin #Deficiency #DKA #Ketoacidosis #Diabetes #Pathophysiology #Endocrinology
and Effects of Insulin ... Deficiency #Insulin ... #Deficiency #DKA ... Pathophysiology #Endocrinology
Pathogenesis of Diabetic Ketoacidosis - Insulin deficiency or severe insulin insensitivity 

#DKA #Pathophysiology #Endocrinology #Diabetes #Ketoacidosis
Ketoacidosis - Insulin ... deficiency or severe insulin ... insensitivity #DKA ... Pathophysiology #Endocrinology
Pathophysiology of Diabetic Ketoacidosis (DKA) and Hyperglycemic Hyperosmolar Syndrome (HHS)
Absolute Insulin deficit:
 - Type I DM:
Ketoacidosis (DKA ... HHS) Absolute Insulin ... Type I DM: No insulin ... Polydipsia #dka ... pathophysiology #comparison #endocrinology
DKA vs HHS
 - Think of DKA and HHS on a spectrum of hyperglycemic emergencies
 -
DKA vs HHS - Think ... of DKA and HHS ... emergencies - HHS = insulin ... restart any home insulin ... laboratory #diagnosis #endocrinology
Pathogenesis and Pathophysiology of Diabetic Ketoacidosis (DKA)

DKA is a result of an absolute or relative insulin
Ketoacidosis (DKA ... ) DKA is a result ... Insulin is the primary ... In DKA, the normal ... #Diabetes #Endocrinology
DKA DIAGNOSTIC CRITERIA:
1. Serum glucose >250 mg/dL
2. Arterial pH <7.3
3. Serum bicarbonate <18 mEq/L
4. At least
DKA DIAGNOSTIC CRITERIA ... Common, early signs ... Continue insulin ... and subcutaneous insulin ... #DKA #EDKA #Insulin
Ketosis Disorders
Ketone bodies are a normal metabolic energy source. Excessive unregulated production of ketones, often accompanied
produce endogenous insulin ... ketoacidosis (DKA ... caused by complete insulin ... HHS) - partial insulin ... diagnosis #management #endocrinology
Diabetic Ketoacidosis (DKA) - Pathogenesis and Clinical Findings
 • Note: in DKA, body K+ is lost
Ketoacidosis (DKA ... along with IV insulin ... +++ fluids. 2) Insulin ... Signs/Symptoms/Complications ... pathophysiology #endocrinology
Sulfonylureas - Pharmacology Summary
Mechanisms of Action: Binds to the ATP-sensitive potassium channel in pancreatic beta cells,
ATP-sensitive potassium ... cells, triggering insulin ... DM2 #diabetes #endocrinology
Diabetic Ketoacidosis 
Management Priorities
1. Fluids 
2. Insulin 
3. Potassium 
4. Acidosis 
5. Re-establish oral fluids,
Insulin 3. ... Potassium 4. ... subcutaneous insulin ... underlying cause #DKA